webTWAS: a resource for disease candidate susceptibility genes identified by transcriptome-wide association study
The development of transcriptome-wide association studies (TWAS) has enabled
researchers to better identify and interpret causal genes in many diseases. However, there …
researchers to better identify and interpret causal genes in many diseases. However, there …
Combining the strengths of inverse-variance weighting and Egger regression in Mendelian randomization using a mixture of regressions model
Z Lin, Y Deng, W Pan - PLoS genetics, 2021 - journals.plos.org
With the increasing availability of large-scale GWAS summary data on various traits,
Mendelian randomization (MR) has become commonly used to infer causality between a …
Mendelian randomization (MR) has become commonly used to infer causality between a …
[HTML][HTML] eQTL studies: from bulk tissues to single cells
An expression quantitative trait locus (eQTL) is a chromosomal region where genetic
variants are associated with the expression levels of specific genes that can be both nearby …
variants are associated with the expression levels of specific genes that can be both nearby …
Conditional transcriptome-wide association study for fine-mapping candidate causal genes
Transcriptome-wide association studies (TWASs) aim to integrate genome-wide association
studies with expression-mapping studies to identify genes with genetically predicted …
studies with expression-mapping studies to identify genes with genetically predicted …
Multiome-wide Association Studies: Novel Approaches for Understanding Diseases
M Shao, K Chen, S Zhang, M Tian… - Genomics …, 2024 - academic.oup.com
The rapid development of multiome (transcriptome, proteome, cistrome, imaging, and
regulome)-wide association study methods have opened new avenues for biologists to …
regulome)-wide association study methods have opened new avenues for biologists to …
Likelihood-based Mendelian randomization analysis with automated instrument selection and horizontal pleiotropic modeling
Mendelian randomization (MR) is a common tool for identifying causal risk factors
underlying diseases. Here, we present a method, MR with automated instrument …
underlying diseases. Here, we present a method, MR with automated instrument …
METRO: Multi-ancestry transcriptome-wide association studies for powerful gene-trait association detection
Integrative analysis of genome-wide association studies (GWASs) and gene expression
studies in the form of a transcriptome-wide association study (TWAS) has the potential to …
studies in the form of a transcriptome-wide association study (TWAS) has the potential to …
Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia
Transcriptome-wide association studies (TWAS) have been widely used to integrate
transcriptomic and genetic data to study complex human diseases. Within a test dataset …
transcriptomic and genetic data to study complex human diseases. Within a test dataset …
TIGAR-V2: Efficient TWAS tool with nonparametric Bayesian eQTL weights of 49 tissue types from GTEx V8
Standard transcriptome-wide association study (TWAS) methods first train gene expression
prediction models using reference transcriptomic data and then test the association between …
prediction models using reference transcriptomic data and then test the association between …
Aggregating multiple expression prediction models improves the power of transcriptome-wide association studies
Transcriptome-wide association study (TWAS) is an important integrative method for
identifying genes that are causally associated with phenotypes. A key step of TWAS involves …
identifying genes that are causally associated with phenotypes. A key step of TWAS involves …