Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …

Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …

The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …

Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women
to high risk of mortality after delivery. Here, we show that female mice with a cardiomyocyte …

Cardiac remodelling is classified as physiological (in response to growth, exercise and
pregnancy) or pathological (in response to inflammation, ischaemia, ischaemia/reperfusion …

Pregnancy outcomes in patients with pulmonary hypertension remain poor despite
advanced therapies. Although consensus guidelines recommend against pregnancy in …

Cardiovascular diseases are a major cause of complications in pregnancy worldwide, and
the number of patients who develop cardiac problems during pregnancy is increasing …

In general, cardiac hypertrophy (an increase in heart mass) is a poor prognostic sign.
Cardiac enlargement is a characteristic of most forms of heart failure. Cardiac hypertrophy …

Proteins of the interleukin-6 (IL-6) family bind to receptors in the plasma membrane.
Subsequent signal transduction involves activation of the janus kinase (JAK) and signal …

Objective To investigate the effects of high intensity interval training (HIIT) on the maternal
heart, fetuses and placentas of pregnant rats. Methods Female Sprague-Dawley rats were …