Transient receptor potential (TRP) channels in airway toxicity and disease: an update

I Müller, P Alt, S Rajan, L Schaller, F Geiger, A Dietrich - Cells, 2022 - mdpi.com
Our respiratory system is exposed to toxicants and pathogens from both sides: the airways
and the vasculature. While tracheal, bronchial and alveolar epithelial cells form a natural …

TRPC and TRPV channels' role in vascular remodeling and disease

M Martín-Bórnez, I Galeano-Otero, R Del Toro… - International journal of …, 2020 - mdpi.com
Transient receptor potentials (TRPs) are non-selective cation channels that are widely
expressed in vascular beds. They contribute to the Ca2+ influx evoked by a wide spectrum …

Role of macrophage polarization in osteoarthritis

B Chen, H Hong, Y Sun, C Chen… - Experimental and …, 2022 - spandidos-publications.com
Osteoarthritis (OA) is a disease involving the whole joint that seriously reduces the living
standards of individuals. Traditional treatments include physical therapy, administration of …

Are TRPA1 and TRPV1 channel-mediated signalling cascades involved in UVB radiation-induced sunburn?

C Camponogara, SM Oliveira - Environmental Toxicology and …, 2022 - Elsevier
Burn injuries are underappreciated injuries associated with substantial morbidity and
mortality. Overexposure to ultraviolet (UV) radiation has dramatic clinical effects in humans …

Transient receptor potential vanilloid subtype 1: potential role in infection, susceptibility, symptoms and treatment of COVID-19

F Liviero, M Campisi, P Mason, S Pavanello - Frontiers in Medicine, 2021 - frontiersin.org
The battle against the new coronavirus that continues to kill millions of people will be still
long. Novel strategies are demanded to control infection, mitigate symptoms and treatment …

Cannabinoids—A New Perspective in Adjuvant Therapy for Pulmonary Hypertension

A Krzyżewska, M Baranowska-Kuczko… - International Journal of …, 2021 - mdpi.com
Currently, no treatment can completely cure pulmonary hypertension (PH), which can lead to
right ventricular failure and, consequently, death. Therefore, searching for new therapies …

Thoracic Spinal Cord Neuroinflammation as a Novel Therapeutic Target in Pulmonary Hypertension

A Razee, S Banerjee, J Hong, S Magaki, G Fishbein… - …, 2023 - Am Heart Assoc
Background: Pulmonary hypertension (PH) is associated with aberrant sympathoexcitation
leading to right ventricular failure (RVF), arrhythmias, and death. Microglial activation and …

[HTML][HTML] Substance P, proinflammatory cytokines, transient receptor potential vanilloid subtype 1 and COVID-19: a working hypothesis

EE Aguirre-Siancas, E Colona-Vallejos… - Neurología (English …, 2021 - ncbi.nlm.nih.gov
The main clinical feature of COVID-19 is respiratory disease of varying severity, ranging from
mild upper respiratory tract involvement to severe interstitial pneumonia and acute …

Investigating potential TRPV1 positive feedback to explain TRPV1 upregulation in airway disease states

J Xu, M Ghadiri, M Svolos, B McParland… - Drug Development …, 2021 - Taylor & Francis
Objective The airway epithelium is a potential source of pathophysiology through activation
of transient potential receptor vallinoid type 1 (TRPV1) channel. A positive feedback cycle …

Sustancia P, citocinas proinflamatorias, receptor de potencial transitorio vaniloide tipo 1 y COVID-19: una hipótesis de trabajo

EE Aguirre-Siancas, E Colona-Vallejos… - Neurologia …, 2020 - pmc.ncbi.nlm.nih.gov
La COVID-19 se caracteriza principalmente por síntomas respiratorios con diversos grados
de severidad, desde enfermedad leve de las vías respiratorias superiores hasta neumonía …