Cancer is a group of diseases in which cells divide continuously and excessively. Cell
division is tightly regulated by multiple evolutionarily conserved cell cycle control …

Oncogene activation disturbs cellular processes and accommodates a complex landscape
of changes in the genome that contribute to genomic instability, which accelerates mutation …

The cell cycle checkpoint proteins ataxia-telangiectasia-mutated-and-Rad3-related kinase
(ATR) and its major downstream effector checkpoint kinase 1 (CHK1) prevent the entry of …

Mammalian development, adult tissue homeostasis and the avoidance of severe diseases
including cancer require a properly orchestrated cell cycle, as well as error-free genome …

The evolutionally conserved DNA damage response (DDR) and cell cycle checkpoints
preserve genome integrity. Central to these genome surveillance pathways is a protein …

Approximately half of the patients diagnosed with neuroblastoma are classified as having
high-risk disease. This group continues to have inadequate cure rates despite multiagent …

Genome maintenance is a constant concern for cells, and a coordinated response to DNA
damage is required to maintain cellular viability and prevent disease. The ataxia …

Faithful DNA replication is essential to all life. Hydroxyurea (HU) depletes the cells of dNTPs,
which initially results in stalled replication forks that, after prolonged treatment, collapse into …

SLFN11 sensitizes cancer cells to a broad range of DNA-targeted therapies. Here we show
that, in response to replication stress induced by camptothecin, SLFN11 tightly binds …

Accumulation of mutations and chromosomal aberrations is one of the hallmarks of cancer
cells. This enhanced genetic instability is fueled by defects in the genome maintenance …