Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

G-quadruplexes (G4s) are four-stranded nucleic acid structures that arise from the stacking
of G-quartets, cyclic arrangements of four guanines engaged in Hoogsteen base-pairing …

Cell identity is maintained by activation of cell-specific gene programs, regulated by
epigenetic marks, transcription factors and chromatin organization. DNA G-quadruplex (G4) …

Nanoparticles (NPs) decorated with a high density of DNA strands, also known as spherical
nucleic acids (SNAs), are widely used in DNA-programmable assembly, sensing, imaging …

Abstract G-quadruplex (G4) structures formed by guanine-rich nucleic acids are implicated
in essential physiological and pathological processes and serve as important drug targets …

Background Guanine-rich sequences are able to form complex RNA structures termed RNA
G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed …

Nucleic acid sequences able to adopt a G-quadruplex conformation are overrepresented
within the human genome. This evidence strongly suggests that these genomic regions …

Noncoding RNAs are functional transcripts that are not translated into proteins. They
represent the largest portion of the human transcriptome and have been shown to regulate …

Abstract DNA G-Quadruplexes (G4s) formed in oncogene promoters regulate transcription.
The oncogene MYC promoter G4 (MycG4) is the most prevalent G4 in human cancers …

The cationic porphyrin TMPyP4 is a well-established DNA G-quadruplex (G4) binding ligand
that can stabilize different topologies via multiple binding modes. However, TMPyP4 can …