Immunometabolism, which is the metabolic reprogramming of anaerobic glycolysis,
oxidative phosphorylation, and metabolite synthesis upon immune cell activation, has …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
associated with inappropriate activation of lymphocytes, hyperinflammatory responses …

Male gender is protective against multiple sclerosis and other T-cell-mediated autoimmune
diseases. This protection may be due, in part, to higher androgen levels in males. Androgen …

Over the last decade, significant progress has been achieved in defining mechanisms
underlying NLR regulation of immune system function. However, several NLR family …

NLRX1 is a member of the NOD‐like receptor family, a set of pattern recognition receptors
associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its …

NLRX1 is a member of the of the Nod-like receptor (NLR) family, and it represents a unique
pattern recognition molecule (PRM) as it localizes to the mitochondrial matrix in resting …

Neuronal disorders are associated with a profound loss of mitochondrial functions caused
by various stress conditions, such as oxidative and metabolic stress, protein folding or import …

Inflammasomes are multiprotein complexes that can sense pathogen‐associated molecular
patterns and damage‐associated molecular signals. They are involved in the initiation and …

Biomechanical force and pathological angiogenesis are dominant features in fibro-
proliferative disorders. Understanding the role and regulation of the mechanical …

A subset of Nucleotide-binding and leucine-rich repeat-containing receptors (NLRs) function
to mitigate overzealous pro-inflammatory signaling produced by NF-κB activation. Under …