A framework to advance biomarker development in the diagnosis, outcome prediction, and treatment of traumatic brain injury
EA Wilde, IB Wanner, K Kenney, J Gill… - Journal of …, 2022 - liebertpub.com
Multi-modal biomarkers (eg, imaging, blood-based, physiological) of unique traumatic brain
injury (TBI) endophenotypes are necessary to guide the development of personalized and …
injury (TBI) endophenotypes are necessary to guide the development of personalized and …
Alternative RNA splicing modulates ribosomal composition and determines the spatial phenotype of glioblastoma cells
TD Larionova, S Bastola, TE Aksinina, KS Anufrieva… - Nature cell …, 2022 - nature.com
Glioblastoma (GBM) is characterized by exceptionally high intratumoral heterogeneity.
However, the molecular mechanisms underlying the origin of different GBM cell populations …
However, the molecular mechanisms underlying the origin of different GBM cell populations …
ENIGMA brain injury: Framework, challenges, and opportunities
Traumatic brain injury (TBI) is a major cause of disability worldwide, but the heterogeneous
nature of TBI with respect to injury severity and health comorbidities make patient outcome …
nature of TBI with respect to injury severity and health comorbidities make patient outcome …
Proton extrusion during oxidative burst in microglia exacerbates pathological acidosis following traumatic brain injury
Acidosis is among the least studied secondary injury mechanisms associated with
neurotrauma. Acute decreases in brain pH correlate with poor long‐term outcome in patients …
neurotrauma. Acute decreases in brain pH correlate with poor long‐term outcome in patients …
[HTML][HTML] Fast and equilibrium CEST imaging of brain tumor patients at 3T
Chemical exchange saturation transfer (CEST) MRI, versatile for detecting endogenous
mobile proteins and tissue pH, has proved valuable in tumor imaging. However, CEST MRI …
mobile proteins and tissue pH, has proved valuable in tumor imaging. However, CEST MRI …
Mapping intracellular pH in tumors using amide and guanidyl CEST‐MRI at 9.4 T
PS Boyd, J Breitling, A Korzowski… - Magnetic …, 2022 - Wiley Online Library
Purpose In principle, non‐invasive mapping of the intracellular pH (pHi) in vivo is possible
using endogenous chemical exchange saturation transfer (CEST)‐MRI of the amide and …
using endogenous chemical exchange saturation transfer (CEST)‐MRI of the amide and …
Whole brain snapshot CEST at 3T using 3D‐EPI: aiming for speed, volume, and homogeneity
S Mueller, R Stirnberg, S Akbey… - Magnetic resonance …, 2020 - Wiley Online Library
Purpose CEST MRI enables imaging of distributions of low‐concentrated metabolites as
well as proteins and peptides and their alterations in diseases. CEST examinations often …
well as proteins and peptides and their alterations in diseases. CEST examinations often …
Translational neuroimaging in mild traumatic brain injury
Traumatic brain injuries (TBIs) are common with an estimated 27.1 million cases per year.
Approximately 80% of TBIs are categorized as mild TBI (mTBI) based on initial symptom …
Approximately 80% of TBIs are categorized as mild TBI (mTBI) based on initial symptom …
[HTML][HTML] pH regulating mechanisms of astrocytes: A critical component in physiology and disease of the brain
SM Theparambil, G Begum, CR Rose - Cell Calcium, 2024 - Elsevier
Strict homeostatic control of pH in both intra-and extracellular compartments of the brain is
fundamentally important, primarily due to the profound impact of free protons ([H+]) on …
fundamentally important, primarily due to the profound impact of free protons ([H+]) on …
Imaging biomarkers of posttraumatic epileptogenesis
Traumatic brain injury (TBI) affects 2.5 million people annually within the United States
alone, with over 300 000 severe injuries resulting in emergency room visits and hospital …
alone, with over 300 000 severe injuries resulting in emergency room visits and hospital …