In the last years, neuroprotective therapies have attracted the researcher interests as
modern and challenging approach for the treatment of neurodegenerative diseases, aimed …

Glaucoma is a neurodegenerative disease that affects primarily the retinal ganglion cells
(RGCs). Increased intraocular pressure (IOP) is one of the major risk factors for glaucoma …

Purpose Impairment of the trabecular meshwork (TM) is the principal cause of increased
outflow resistance in the glaucomatous eye. Yes-associated protein (YAP) and …

Trabecular meshwork (TM) tissue is subjected to constant mechanical stress due to the
ocular pulse created by the cardiac cycle. This brings about alterations in the membrane …

Purpose To investigate the association of systemic oxidative stress markers and optic nerve
head (ONH) blood flow in normal-tension glaucoma (NTG) patients, as well as sex …

Glaucoma is the leading cause of irreversible blindness. Current treatment options are
limited and often only slow disease progression. Metabolic dysfunction has recently been …

Metabolic traits are associated with the risk of developing glaucoma in observational
studies. To assess whether theses associations reflect causality, we conducted a Mendelian …

Background The endocannabinoid system (ECS) is a complex biological regulatory system.
Its expression and functionality have been widely investigated in ocular tissues. Recent data …

Featured Application Compromised light perception, as with retinal ganglion cell loss, is
associated with serum lipids being unevenly altered in the morning vs. the evening …

Glaucoma is a group of ocular diseases that cause irreversible blindness. It is characterized
by multifactorial degeneration of the optic nerve axons and retinal ganglion cells (RGCs) …