Viruses are major pathogenic agents that can cause a variety of serious diseases in
humans, other animals, and plants. Due to their clinical and scientific importance, viruses …

The Hepatitis C virus is a positive-stranded RNA virus which is the causal agent for a chronic
liver infection afflicting more than 170,000,000 people world-wide. The HCV genome is …

The hepatitis C virus (HCV) is the etiologic agent of chronic hepatitis C infection, an
important health problem that can lead to cirrhosis of the liver and hepatocellular carcinoma …

The inadequate efficacy and tolerability of current therapies for the infectious liver disease
caused by the hepatitis C virus have warranted significant efforts in the development of new …

Hepatitis C virus (HCV) is a common pathogen with an estimated 170 million people
infected worldwide in the year 2000. 1 The virus was unambiguously identified in 1989 as …

Autoantibodies to smooth muscle (SMA) and nuclear components (ANA) arise in the natural
course of chronic infection with hepatitis C virus. In view of the growing evidence for …

Proteolytic processing of the dengue virus polyprotein is mediated by host cell proteases
and the virus-encoded NS2B-NS3 two-component protease. The NS3 protease represents …

Abstract Since 2011 Direct Acting antivirals (DAAs) drugs targeting different non-structural
(NS) viral proteins (NS3, NS5A or NS5B inhibitors) have been approved for clinical use in …

The NS3 serine protease enzyme of the hepatitis C virus (HCV) is essential for viral
replication. Short peptides mimicking the N-terminal substrate cleavage products of the NS3 …

The virally encoded NS3 protease is essential to the life cycle of the hepatitis C virus (HCV),
an important human pathogen causing chronic hepatitis, cirrhosis of the liver, and …