Rodent models of rheumatoid arthritis (RA) have been used over decades to study the
immunopathogenesis of the disease and to explore intervention strategies. Nevertheless …

Animal models have been used extensively in studies of rheumatoid arthritis pathogenesis.
Despite the inherent limitations of all animal models, several rodent models have …

MHC class II (MHC-II) molecules play a central role in the selection of the T cell repertoire, in
the establishment and regulation of the adaptive immune response, and in autoimmune …

Predisposition co develop Various autoimmune disorders has been associated with certain
HLA class II molecules but there is a lack of information on che pathophysiological rule of …

Genetic predisposition to rheumatoid arthritis (RA) is linked to the MHC class II allele HLA-
DR4. The charge of the amino acid at DRβ71 in the peptide-binding site appears to be …

To investigate the development of HLA-DR-associated autoimmune diseases, we generated
transgenic (Tg) mice with HLA-DRA-IE alpha and HLA-DRB1* 0401-IE beta chimeric genes …

Rheumatoid arthritis (RA) is associated with certain MHC class II alleles and is characterized
by a chronic autoimmune response in the joints. Using transgenic mice expressing human …

Susceptibility to anti-glomerular basement membrane disease is strongly associated with
HLA-DRB1 genes. Anti-glomerular basement membrane (anti-GBM) disease is caused by …

Rheumatoid arthritis (RA) is an autoimmune disease associated with the HLA-DR4 and DR1
alleles. The target autoantigen (s) in RA is unknown, but type II collagen (CII) is a candidate …

Genetic studies have indicated that susceptibility to rheumatoid arthritis (RA) maps to the
HLA-DR locus of the major histocompatibility complex. Strong linkage disequilibrium …