Vascular endothelial cells (ECs), the inner layer of blood vessels, were previously
considered to be a passive lining that facilitates cellular and molecular exchange. However …

Aldehyde dehydrogenase 2 (ALDH2) is an enzyme found in the mitochondrial matrix that
plays a central role in alcohol and aldehyde metabolism. A common ALDH2 polymorphism …

Background Empagliflozin (EMPA) ameliorates reactive oxygen species (ROS) generation
in human endothelial cells (ECs) exposed to 10% stretch, but the underlying mechanisms …

Background SGLT2i reduce cardiac hypertrophy, but underlying mechanisms remain
unknown. Here we explore a role for serine/threonine kinases (STK) and sodium hydrogen …

Background: SGLT2i directly inhibit the cardiac sodium-hydrogen exchanger-1 (NHE1) in
isolated ventricular cardiomyocytes (CMs). However, other studies with SGLT2i have yielded …

Human induced pluripotent stem cell (iPSC) platforms are valuable for biomedical and
pharmaceutical research by providing tissue-specific human cells that retain patients' …

The medical disorders of alcoholism rank among the leading public health problems
worldwide and the need for predictive and prognostic risk markers for assessing alcohol use …

Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by
hyperglycaemia. T2DM is a highly heterogeneous polygenic disease. Due to genetic …

Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) were initially recommended as oral
anti-diabetic drugs to treat type 2 diabetes (T2D), by inhibiting SGLT2 in proximal tubule and …

This systematic review and meta-analysis aimed to determine the association between the
use of sodium-glucose cotransporter 2 (SGLT-2) inhibitors and dementia onset as well as …