Psychiatry faces fundamental challenges with regard to mechanistically guided differential
diagnosis, as well as prediction of clinical trajectories and treatment response of individual …

Brain function relies on efficient communications between distinct brain systems. The
pathology of major depressive disorder (MDD) damages functional brain networks, resulting …

The human isocortex consists of tangentially organized layers with unique cytoarchitectural
properties. These layers show spatial variations in thickness and cytoarchitecture across the …

We present a didactic introduction to spectral dynamic causal modeling (DCM), a Bayesian
state-space modeling approach used to infer effective connectivity from noninvasive …

Psychedelics have emerged as promising candidate treatments for various psychiatric
conditions, and given their clinical potential, there is a need to identify biomarkers that …

Background While the exploration of serotonergic psychedelics as psychiatric medicines
deepens, so does the pressure to better understand how these compounds act on the brain …

The habenula has been implicated in the pathogenesis of pain and analgesia, while
evidence concerning its function in chronic low back pain (cLBP) is sparse. This study aims …

Dysfunction of fronto-striato-thalamic (FST) circuits is thought to contribute to dopaminergic
dysfunction and symptom onset in psychosis, but it remains unclear whether this dysfunction …

Huntington's and Parkinson's disease are two movement disorders representing mainly
opposite states of the basal ganglia inhibitory function. Despite being an integral part of the …

Temporal lobe epilepsy (TLE) is the most common pharmaco-resistant epilepsy in adults.
While primarily associated with mesiotemporal pathology, recent evidence suggests that …