Biological and clinical significance of haptoglobin polymorphism in humans

MR Langlois, JR Delanghe - Clinical chemistry, 1996 - academic.oup.com
Haptoglobin is a hemoglobin-binding protein expressed by a genetic polymorphism as three
major phenotypes: 1-1, 2-1, and 2-2. Most attention has been paid to determining …

Haptoglobin: From hemoglobin scavenging to human health

A di Masi, G De Simone, C Ciaccio, S D'Orso… - Molecular Aspects of …, 2020 - Elsevier
Haptoglobin (Hp) belongs to the family of acute-phase plasma proteins and represents the
most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric …

The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium …

S Devaraj, D Li, IJ Jialal - The Journal of clinical …, 1996 - Am Soc Clin Investig
Low levels of alpha tocopherol are related to a higher incidence of cardiovascular disease
and increased intake appears to afford protection against cardiovascular disease. In …

Highly reactive oxygen species: detection, formation, and possible functions

W Freinbichler, MA Colivicchi, C Stefanini… - Cellular and molecular …, 2011 - Springer
The so-called reactive oxygen species (ROS) are defined as oxygen-containing species that
are more reactive than O 2 itself, which include hydrogen peroxide and superoxide …

What is responsible for the initiating chemistry of iron-mediated lipid peroxidation: an update

Z Cheng, Y Li - Chemical Reviews, 2007 - ACS Publications
In the past few decades, extensive studies have been performed and have shown the
causative role of ironmediated lipid peroxidation (LPO) in human diseases and in the …

[HTML][HTML] Comparison of the antioxidant effects of Concord grape juice flavonoids α-tocopherol on markers of oxidative stress in healthy adults

DJ O'Byrne, S Devaraj, SM Grundy, I Jialal - The American journal of …, 2002 - Elsevier
Background: Concord grape juice (CGJ) is a rich source of flavonoids, which have greater
antioxidant efficacy in vitro than does α-tocopherol; however, the efficacies of flavonoids and …

Donation of blood is associated with reduced risk of myocardial infarction: the Kuopio Ischaemic Heart Disease Risk Factor Study

JT Salonen, TP Tuomainen, R Salonen… - American journal of …, 1998 - academic.oup.com
Because high body iron stores have been suggested as a risk factor for acute myocardial
infarction, donation of blood could theoretically reduce the risk by lowering body iron stores …

Melatonin ameliorates low‐grade inflammation and oxidative stress in young Zucker diabetic fatty rats

A Agil, RJ Reiter, A Jiménez‐Aranda… - Journal of pineal …, 2013 - Wiley Online Library
The aim of this study was to investigate the effects of melatonin on low‐grade inflammation
and oxidative stress in young male Zucker diabetic fatty (ZDF) rats, an experimental model of …

Role of inflammation (leukocyte-endothelial cell interactions) in vasospasm after subarachnoid hemorrhage

KL Chaichana, G Pradilla, J Huang, RJ Tamargo - World neurosurgery, 2010 - Elsevier
BACKGROUND: Delayed vasospasm is the leading cause of morbidity and mortality after
aneurysmal subarachnoid hemorrhage (aSAH). This phenomenon was first described more …

Comparison of the effect of α-lipoic acid and α-tocopherol supplementation on measures of oxidative stress

K Marangon, S Devaraj, O Tirosh, L Packer… - Free Radical Biology and …, 1999 - Elsevier
In vitro studies have shown that α-lipoic acid (LA) is an antioxidant. There is a paucity of
studies on LA supplementation in humans. Therefore, the aim of this study was to assess the …