Patients with irritable bowel syndrome (IBS) are increasingly presenting with a wide range of
neuropsychiatric symptoms, such as deterioration in gastroenteric physiology, including …

Background Chronic pain is common in adults, and often has a detrimental impact upon
physical ability, well‐being, and quality of life. Previous reviews have shown that certain …

Background Abdominal pain is a core symptom of IBS and a primary driver of care seeking.
Visceral hypersensitivity is a key pathophysiological mechanism and therapeutic target for …

Keywords: FUNCTIONAL DISEASES OF THE DIGESTIVE SYSTEM, FUNCTIONAL
HEARTBURN, FUNCTIONAL DYSPEPSIA, BILIARY DYSFUNCTION, IRRITABLE BOWEL …

Description This expert review summarizes approaches to management of pain in disorders
of gut–brain interaction. This review focuses specifically on approaches to pain that persist if …

Disorders of gut-brain interaction, previously known as functional gastrointestinal disorders
(eg, functional dyspepsia and irritable bowel syndrome), are commonly encountered in both …

Background & Aims Fecal urgency, which is defined by the sudden need to rush to the
bathroom to empty one's bowel, is one of the common and distressing symptoms …

Background Central neuromodulators are an effective treatment for irritable bowel syndrome
(IBS) but may be used less frequently than other therapies. Aims To survey …

Postprandial, or meal-related, symptoms, such as abdominal pain, early satiation, fullness or
bloating, are often reported by patients with disorders of gut-brain interaction, including …

Azepanes or azepines are structural motifs of many drugs, drug candidates and evaluated
lead compounds. Even though compounds having N-heterocyclic 7-membered rings are …