Copper (I)-catalyzed 1, 3-dipolar cycloaddition between organic azides and terminal
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …

Cu (I)-catalyzed azide–alkyne 1, 3-dipolar cycloaddition (CuAAC), popularly known as the
“click reaction”, serves as the most potent and highly dependable tool for facile construction …

Oligonucleotides (ONs), and their chemically modified mimics, are now routinely used in the
laboratory as a means to control the expression of fundamentally interesting or …

Small interfering RNA s (si RNA s) are one of the valuable tools to investigate the functions
of genes and are also used for gene silencing. It has a wide scope in drug discovery through …

Conspectus Protein biosynthesis is a central process in all living cells that is catalyzed by a
complex molecular machine─ the ribosome. This process is termed translation because the …

RNA is often considered as being the vector for the transmission of genetic information from
DNA to the protein synthesis machinery. However, besides translation RNA participates in a …

Bioorthogonal reactions are of high interest in biosciences as they allow the introduction of
fluorescent dyes, affinity tags, or other unnatural moieties into biomolecules. The site …

One of the major constraints on the therapeutic use of oligonucleotides is inefficient delivery
to their sites of action in the cytosol or nucleus. Recently it has become evident that the …

RNA is becoming more important as an increasing number of functions, both regulatory and
enzymatic, are being discovered on a daily basis. As the RNA boom has just begun, most …

Bioorthogonal chemistry has mainly been developed for proteins and carbohydrates. The
chemistry of nucleic acids is different, and bioorthogonal labeling strategies that were …