Major depressive disorder

W Marx, BWJH Penninx, M Solmi… - Nature Reviews …, 2023 - nature.com
Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

Reviewing the neurobiology of electroconvulsive therapy on a micro-meso-and macro-level

JB Belge, P Mulders, L Van Diermen, P Sienaert… - Progress in Neuro …, 2023 - Elsevier
Background Electroconvulsive therapy (ECT) remains the one of the most effective of
biological antidepressant interventions. However, the exact neurobiological mechanisms …

The immune profile of major dysmood disorder: proof of concept and mechanism using the precision nomothetic psychiatry approach

M Maes, M Rachayon, K Jirakran, P Sodsai… - Cells, 2022 - mdpi.com
Major depressive disorder and a major depressive episode (MDD/MDE) are characterized
by activation of the immune-inflammatory response system (IRS) and the compensatory …

Baseline levels of miR-223-3p correlate with the effectiveness of electroconvulsive therapy in patients with major depression

L Kaurani, M Besse, I Methfessel, A Methi… - Translational …, 2023 - nature.com
There is a strong medical need to develop suitable biomarkers to improve the diagnosis and
treatment of depression, particularly in predicting response to certain therapeutic …

Human in vivo evidence of reduced astrocyte activation and neuroinflammation in patients with treatment‐resistant depression following electroconvulsive therapy

S Xu, X Xie, L Yao, W Wang, H Zhang… - Psychiatry and …, 2023 - Wiley Online Library
Aim The current study aimed to investigate the neuroinflammatory hypothesis of depression
and the potential anti‐inflammatory effect of electroconvulsive therapy (ECT) in vivo, utilizing …

[HTML][HTML] Peripheral blood inflammatory markers in depression: Response to electroconvulsive therapy and relationship with cognitive performance

KM Ryan, DM McLoughlin - Psychiatry Research, 2022 - Elsevier
The inflammatory response may play a role in depression and the response to
antidepressants. Electroconvulsive therapy (ECT), the most acutely powerful antidepressant …

Immune-inflammatory markers of response to repetitive transcranial magnetic stimulation in depression: a scoping review

RP Rajkumar - Asian Journal of Psychiatry, 2024 - Elsevier
Background Repetitive transcranial magnetic stimulation (rTMS) is a safe, effective and non-
invasive form of neuromodulatory therapy in patients with major depressive disorder (MDD) …

[HTML][HTML] White matter integrity and pro-inflammatory cytokines as predictors of antidepressant response in MDD

S Breit, E Mazza, S Poletti, F Benedetti - Journal of psychiatric research, 2023 - Elsevier
Major depressive disorder (MDD) is a multifactorial, serious and heterogeneous mental
disorder that can lead to chronic recurrent symptoms, treatment resistance and suicidal …

Major depressive disorder in older patients as an inflammatory disorder: implications for the pharmacological management of geriatric depression

MP Forbes, A O'Neil, M Lane, B Agustini, N Myles… - Drugs & Aging, 2021 - Springer
Depression is a common and highly disabling condition in older adults. It is a heterogenous
disorder and there is emerging evidence of a link between inflammation and depression in …

Fecal metabolomics and network pharmacology reveal the correlations between constipation and depression

X Liu, H Liu, F Wei, D Zhao, Y Wang, M Lv… - Journal of Proteome …, 2021 - ACS Publications
Constipation and depression are tightly related and often co-occur and coexist in clinic. Yet,
the relationships and the underlying mechanisms are still unclear. Fecal metabolomics and …