Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

Epigenetic modifications include DNA methylation and covalent modification of histones.
These alterations are reversible but very stable and exert a significant impact on the …

Alterations in TP53 have been described in many cancer types including hematological
neoplasms. We aimed at comparing TP53 mutations (mut) and deletions (del) in a large …

MicroRNAs (miRNAs) are RNA sequences of∼ 22 nucleotides that mediate post-
transcriptional regulation of specific mRNAs. miRNA sequences are dispersed throughout …

When looking for a book on fish toxicology, you might find one that discusses the
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …

Mutations of the TP53 gene and dysregulation of the TP53 pathway are important in the
pathogenesis of many human cancers, including lymphomas. Tumor suppression by p53 …

TP53 is the most extensively studied gene in cancer. However, data on frequency and the
prognostic impact of TP53 mutations in acute lymphoblastic leukemia (ALL) remain scarce …

Innate and acquired resistance towards the conventional therapeutic regimen imposes a
significant challenge for the successful management of cancer for decades. In patients with …

Background & Aims: Interleukin 6 (IL-6)-mediated signal transducers and activators of
transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in …

Abstract p53 is a powerful tumor suppressor and is an attractive cancer therapeutic target. A
breakthrough in cancer research came from the discovery of the drugs which are capable of …