SUMOylation is a reversible post-translational modification which has emerged as a crucial
molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune …

Mammalian cells harness autophagy to eliminate physiological byproducts of metabolism
and cope with microenvironmental perturbations. Moreover, autophagy connects cellular …

SUMOylation, as a post-translational modification, plays essential roles in various biological
functions including cell growth, migration, cellular responses to stress and tumorigenesis …

Human papillomavirus (HPV) is a class of envelope-free double-stranded DNA virus. HPV
infection has been strongly associated with the development of many malignancies, such as …

Human papilloma viruses (HPVs) are a group of double-stranded DNA viruses known to be
the primary cause of cervical cancer. In addition, evidence has now established their role in …

Lamins are the ancient type V intermediate filament proteins contributing to diverse
biological functions, such as the maintenance of nuclear morphology, stabilization of …

Background Cervical cancer, a pernicious gynecological malignancy, causes the mortality of
hundreds of thousands of females worldwide. Despite a considerable decline in mortality …

People with cystic fibrosis should be considered at increased risk of developing severe
symptoms of COVID-19. Strikingly, a broad array of evidence shows reduced spread of …

SUMOylation dynamically conjugates SUMO molecules to the lysine residue of a substrate
protein, which depends on the physiological state of the cell and the attached SUMO …

Vascular calcification (VC) is caused by hydroxyapatite deposition in the intimal and medial
layers of the vascular wall, leading to severe cardiovascular events in patients with …