The shape and form of protozoan parasites are inextricably linked to their pathogenicity. The
evolutionary pressure associated with establishing and maintaining an infection and …

Trypanosoma brucei is a pathogenic unicellular eukaryote that infects humans and other
mammals in sub-Saharan Africa. A central feature of trypanosome biology is the single …

Trypanosoma brucei is a model trypanosomatid, an important group of human, animal and
plant unicellular parasites. Understanding their complex cell architecture and life cycle is …

Trypanosomes are important disease agents and excellent models for the study of
evolutionary cell biology. The trypanosome flagellar pocket is a small invagination of the …

The cell cycle is central to understanding fundamental biology of Leishmania, a group of
human‐infective protozoan parasites. Leishmania have two main life cycle morphologies …

African trypanosomes are unicellular flagellated parasites causing trypanosomiases in
Africa, a group of severe diseases also known as sleeping sickness in human and nagana …

The first description of African trypanosomes was made over a century ago. The importance
of the tsetse in transmission and cyclic development of trypanosomes was discovered soon …

Survival in and colonization of the tsetse fly midgut are essential steps in the transmission of
many species of African trypanosomes. In the fly, bloodstream trypanosomes transform into …

The use of glycosylphosphatidylinositol (GPI) to anchor proteins to the cell surface is
widespread among eukaryotes. The GPI-anchor is covalently attached to the C-terminus of a …

The long and complex Trypanosoma brucei development in the tsetse fly vector culminates
when parasites gain mammalian infectivity in the salivary glands. A key step in this process …