The use of medicinal plant-derived metallic nanoparticles in theranostics

JH Xulu, T Ndongwe, KM Ezealisiji, VJ Tembu… - Pharmaceutics, 2022 - mdpi.com
In the quest to effectively diagnose and treat the diseases that afflict mankind, the
development of a tool capable of simultaneous detection and treatment would provide a …

Biocompatibility of biomaterials for nanoencapsulation: Current approaches

BA Witika, PA Makoni, SK Matafwali, B Chabalenge… - Nanomaterials, 2020 - mdpi.com
Nanoencapsulation is an approach to circumvent shortcomings such as reduced
bioavailability, undesirable side effects, frequent dosing and unpleasant organoleptic …

Effect of concentration of TiC on the properties of pulse electrodeposited Ni–P–TiC nanocomposite coatings

K Shahzad, AB Radwan, O Fayyaz, RA Shakoor… - Ceramics …, 2021 - Elsevier
Ni–P/TiC nanocomposite coatings, including different concentrations of TiC nanoparticles
(TCNPs) were developed on HSLA (high strength low alloy steel) substrates through the …

[HTML][HTML] Formulation and optimization of transferrin-modified genistein nanocrystals: In vitro anti-cancer assessment and pharmacokinetic evaluation

FM Iqbal, C Rodríguez-Nogales, N Boulens… - International Journal of …, 2024 - Elsevier
In this research work, nanocrystals (NC) of poorly water-soluble drug genistein (Gen) were
formulated to improve its aqueous solubility and bioavailability. Genistein nanocrystals (Gen …

Quality by design optimization of cold sonochemical synthesis of zidovudine-lamivudine nanosuspensions

BA Witika, VJ Smith, RB Walker - Pharmaceutics, 2020 - mdpi.com
Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used to manage HIV/AIDS
infection. The compounds require frequent dosing, exhibit unpredictable bioavailability and …

Nano-and crystal engineering approaches in the development of therapeutic agents for neoplastic diseases

EM Kiyonga, LN Kekani, TV Chidziwa, KD Kahwenga… - Crystals, 2022 - mdpi.com
Cancer is a leading cause of death worldwide. It is a global quandary that requires the
administration of many different active pharmaceutical ingredients (APIs) with different …

Nano co-crystal embedded stimuli-responsive hydrogels: A potential approach to treat HIV/AIDS

BA Witika, JC Stander, VJ Smith, RB Walker - Pharmaceutics, 2021 - mdpi.com
Currently, the human immunodeficiency virus (HIV) that causes acquired immunodeficiency
syndrome (AIDS) can only be treated successfully, using combination antiretroviral (ARV) …

Top-down synthesis of a lamivudine-zidovudine nano co-crystal

BA Witika, VJ Smith, RB Walker - Crystals, 2020 - mdpi.com
Lamivudine (3TC) and zidovudine (AZT) are antiretroviral agents used to manage HIV/AIDS
infection. A wet media milling top-down approach was used to develop and produce nano …

Cocrystal applications in drug delivery

A Erxleben - Pharmaceutics, 2020 - mdpi.com
Over the past two decades, considerable research efforts in academia and industry have
gone into pharmaceutical cocrystals [1, 2]. As a result, a large number of studies on both …

Development of eplerenone nano sono-crystals using factorial design: enhanced solubility and dissolution rate via anti solvent crystallization technique

GE Yassin, MKA Khalifa - Drug Development and Industrial …, 2022 - Taylor & Francis
Objective The purpose of this work was to improve EP solubility by using a sono-
crystalization approach to reduce particle size and hence, increase the dissolution rate …