Recent advances in bioprinting techniques: approaches, applications and future prospects
J Li, M Chen, X Fan, H Zhou - Journal of translational medicine, 2016 - Springer
Bioprinting technology shows potential in tissue engineering for the fabrication of scaffolds,
cells, tissues and organs reproducibly and with high accuracy. Bioprinting technologies are …
cells, tissues and organs reproducibly and with high accuracy. Bioprinting technologies are …
Microfluidic organ-on-a-chip models of human liver tissue
The liver is the largest internal organ of the body with complex microarchitecture and
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …
Reproducing human and cross-species drug toxicities using a Liver-Chip
Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate
drugs may produce discordant results or fail to predict complications in humans, contributing …
drugs may produce discordant results or fail to predict complications in humans, contributing …
Fluorescent probe for the imaging of superoxide and peroxynitrite during drug-induced liver injury
Drug-induced liver injury (DILI) is an important cause of potentially fatal liver disease.
Herein, we report the development of a molecular probe (LW-OTf) for the detection and …
Herein, we report the development of a molecular probe (LW-OTf) for the detection and …
3D bioprinting in tissue engineering for medical applications: the classic and the hybrid
Three-dimensional (3D) printing, as one of the most popular recent additive manufacturing
processes, has shown strong potential for the fabrication of biostructures in the field of tissue …
processes, has shown strong potential for the fabrication of biostructures in the field of tissue …
[HTML][HTML] Organs-on-chips technologies–A guide from disease models to opportunities for drug development
Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …
human physiopathology with striking discrepancies in estimating drug efficacy and side …
Liver 'organ on a chip'
The liver plays critical roles in both homeostasis and pathology. It is the major site of drug
metabolism in the body and, as such, a common target for drug-induced toxicity and is …
metabolism in the body and, as such, a common target for drug-induced toxicity and is …
Towards artificial tissue models: past, present, and future of 3D bioprinting
Regenerative medicine and tissue engineering have seen unprecedented growth in the past
decade, driving the field of artificial tissue models towards a revolution in future medicine …
decade, driving the field of artificial tissue models towards a revolution in future medicine …
A critical perspective on 3D liver models for drug metabolism and toxicology studies
AS Serras, JS Rodrigues, M Cipriano… - Frontiers in cell and …, 2021 - frontiersin.org
The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …
A microfluidically perfused three dimensional human liver model
K Rennert, S Steinborn, M Gröger, B Ungerböck… - Biomaterials, 2015 - Elsevier
Within the liver, non-parenchymal cells (NPCs) are critically involved in the regulation of
hepatocyte polarization and maintenance of metabolic function. We here report the …
hepatocyte polarization and maintenance of metabolic function. We here report the …