Objective: There is burgeoning interest in augmentation strategies for improving inadequate
response to antidepressants. The adjunctive use of standardized pharmaceutical-grade …

Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Background/Aims. Low serum folate levels can alter inflammatory reactions. Both
phenomena have been linked to Alzheimer's disease (AD), but the effect of folic acid on AD …

Episodes of depression and anxiety commonly follow the experience of stress, however not
everyone who experiences stress develops a mood disorder. Individuals who are able to …

The management of fatigue associated with chronic liver disease is a complex and major
clinical challenge. Although fatigue can complicate many chronic diseases, it is particularly …

Studies over the past decade have revealed that metabolism profoundly influences immune
responses. In particular, metabolism causes epigenetic regulation of gene expression, as a …

Abstract S-Adenosyl methionine (SAMe), as a major methyl donor, exerts its influence on
central nervous system function through cellular transmethylation pathways, including the …

Identifying markers of human insulin resistance may permit development of new approaches
for treatment and prevention of type 2 diabetes. To this end, we analyzed the fasting plasma …

Hepatic fibrosis and cirrhosis cause strong human suffering and necessitate a monetary
burden worldwide. Therefore, there is an urgent need for the development of therapies. Pre …

Depression is a common and serious health issue affecting around 280 million people
around the world. Suicidal ideation more frequently occurs in people with moderate to …