Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

NFE2-like basic leucine zipper transcription factor 2 (NFE2L2, also known as NRF2), is a
key transcription factor in the cellular defense against oxidative stress, playing a crucial role …

Reduction of amyloid beta (Aβ) has been shown to be effective in treating Alzheimer's
disease (AD), but the underlying assumption that neurons are the main source of pathogenic …

Type 2 diabetes (T2D), a prevalent metabolic disorder lacking effective treatments, is
associated with lysosomal acidification dysfunction, as well as autophagic and mitochondrial …

Autophagy is a fundamental biological process critical to all eukaryotic cellular life. Although
autophagy has been increasingly studied, how its process is precisely coordinated remains …

PANoptosis, a complex form of proinflammatory programmed cell death, including
apoptosis, pyroptosis and necroptosis, has been an emerging concept in recent years that …

A cell death pathway, ferroptosis, occurs in conidial cells and is critical for formation and
function of the infection structure, the appressorium, in the rice blast fungus Magnaporthe …

As a self‐degrading and highly conserved survival mechanism, autophagy plays an
important role in maintaining cell survival and recycling. The discovery of autophagy‐related …

Autophagy is a key lysosomal degradative mechanism allowing a prosurvival response to
stresses, especially nutrient starvation. Here we investigate the mechanism of autophagy …

Listeria monocytogenes (L. monocytogenes, Lm) is widely used in the laboratory as an
infection model for the research on pathogenesis and host defense against gram-positive …