Simple Summary Tumor stroma is known to significantly influence cancer initiation and
progression. In the last decade, 3D cell cultures have shown potential in modeling the tumor …

All terrestrial organisms have evolved and adapted to thrive under Earth's gravitational force.
Due to the increase of crewed space flights in recent years, it is vital to understand how the …

Distinct anti-inflammatory macrophage (M2) subtypes, namely M2a and M2c, are reported to
modulate the tissue repair process tightly and chronologically by modulating fibroblast …

Type I collagen self-assembles into three-dimensional (3D) fibrous networks. These
dynamic viscoelastic materials can be remodeled in response to mechanical and chemical …

Bioinks for 3D bioprinting of tumor models should not only meet printability requirements but
also accurately maintain and support phenotypes of tumor surrounding cells to recapitulate …

Extracellular matrix stiffening of breast tissues has been clinically correlated with malignant
transformation and poor prognosis. An increase of collagen fibril diameter and lysyl-oxidase …

Collagen fibers in the 3D tumor microenvironment (TME) exhibit complex alignment
landscapes that are critical in directing cell migration through a process called contact …

The extracellular matrix (ECM) establishes the basis for the cell's microenvironment
providing structural and mechanical support to cells and tissues, and regulating multiple cell …

Monocytes circulate in the bloodstream, extravasate into the tissue and differentiate into
specific macrophage phenotypes to fulfill the immunological needs of tissues. During the …

Hyaluronan (HA) and its principal receptor CD44 are known to be involved in regulating
tumor cell dissemination and metastasis. The direct correlation of CD44-HA interaction on …