Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Over the past ten years, numerous chemokines have been identified as attractants of
different types of blood leukocytes to sites of infection and inflammation. They are produced …

Regulatory T (Treg) cells reside in lymphoid organs and barrier tissues where they control
different types of inflammatory responses. Treg cells are also found in human cancers, and …

Tumor-derived extracellular vesicles are important mediators of cell-to-cell communication
during tumorigenesis. Here, we demonstrated that hepatocellular carcinoma (HCC)-derived …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

The current study identifies CCR8+ regulatory T cells (Treg cells) as drivers of
immunosuppression. We show that in human peripheral blood cells, more than 30% of Treg …

Chemokines are essential mediators of normal leukocyte trafficking as well as of leukocyte
recruitment during inflammation. We describe here a novel non-ELR CXC chemokine …

Although most leukocytes, T lymphocytes in particular, respond to several different
chemokines, there is virtually no information on chemokine activities and chemokine …

Chemokines are small peptides that are potent activators and chemoattractants for leukocyte
subpopulations and some nonhemopoietic cells. Their actions are mediated by a family of 7 …

Chemokines are a family of low molecular weight proteins with an essential role in leukocyte
trafficking during both homeostasis and inflammation. The CC class of chemokines consists …