NO and its derivatives can have multiple effects, which impact on neuronal death in different
ways. High levels of NO induces energy depletion-induced necrosis, due to:(i) rapid …

Since the original identification of microglia as a principal player in the brain's innate
immune response, microglial activation has been widely studied. Recent studies suggest …

We demonstrate that the 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A (HMG‐CoA) reductase
inhibitors atorvastatin and simvastatin enhance functional outcome and induce brain …

Primary dissociated neuronal cultures have been intensively exploited for the past 15 years
as model systems to investigate excitotoxic neuronal degeneration. Even this simplified …

Nitric oxide (NO), plays multiple roles in the nervous system. In addition to regulating
proliferation, survival and differentiation of neurons, NO is involved in synaptic activity …

Various lines of evidence indicate the presence of progressive pathophysiological
processes occurring within the brains of patients with schizophrenia. By modulating …

The subventricular zone of the rodent brain retains the capacity of generating new neurons
in adulthood. The newly formed neuroblasts migrate rostrally toward the olfactory bulb …

Objective Glutamic acid decarboxylase (GAD) catalyzes the conversion of glutamic acid into
GABA. GAD autoantibodies (GAD‐Ab) have been described in diabetes mellitus and in …

Nitric oxide (NO), an important cellular messenger, has been linked to both
neurodegenerative and neuroprotective actions. In the present review, we focus on recent …

The role of the neural messenger nitric oxide (NO) in cerebral ischaemia has been
investigated extensively in the past decade. NO may play either a protective or destructive …