Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …

Mitochondria are key cell organelles in that they are responsible for energy production and
control many processes from signalling to cell death. The function of the mitochondrial …

Decades of research indicate mitochondria from Alzheimer's disease (AD) patients differ
from those of non-AD individuals. Initial studies revealed structural differences, and …

Alzheimer's disease (AD) is the most common cause of dementia and a great
socioeconomic burden in the aging society. Compelling evidence demonstrates that …

Life is the interplay between structure and energy, yet the role of energy deficiency in human
disease has been poorly explored by modern medicine. Since the mitochondria use …

The distinguishing pathogenic features of neurodegenerative diseases include
mitochondrial dysfunction and derived reactive oxygen species generation. The neural …

Viable Alzheimer's disease (AD) hypotheses must account for its age-dependence;
commonality; association with amyloid precursor protein, tau, and apolipoprotein E biology; …

We first proposed the mitochondrial cascade hypothesis of sporadic Alzheimer's disease
(AD) in 2004. Our core assumptions were a person's genes determine baseline …

Considerable evidence suggests that mitochondrial dysfunction and oxidative stress
contribute to the progression of Alzheimer's disease (AD). We examined the ability of the …

Alzheimer's disease (AD) includes etiologically heterogenous disorders characterized by
senile or presenile dementia, extracellular amyloid protein aggregations containing an …