Monogenic diabetes
Monogenic diabetes includes several clinical conditions generally characterized by early-
onset diabetes, such as neonatal diabetes, maturity-onset diabetes of the young (MODY) …
onset diabetes, such as neonatal diabetes, maturity-onset diabetes of the young (MODY) …
Monogenic diabetes: a gateway to precision medicine in diabetes
Monogenic diabetes refers to diabetes mellitus (DM) caused by a mutation in a single gene
and accounts for approximately 1%–5% of diabetes. Correct diagnosis is clinically critical for …
and accounts for approximately 1%–5% of diabetes. Correct diagnosis is clinically critical for …
Human pancreas development
RE Jennings, AA Berry, JP Strutt, DT Gerrard… - …, 2015 - journals.biologists.com
A wealth of data and comprehensive reviews exist on pancreas development in mammals,
primarily mice, and other vertebrates. By contrast, human pancreatic development has been …
primarily mice, and other vertebrates. By contrast, human pancreatic development has been …
[HTML][HTML] The effect of early, comprehensive genomic testing on clinical care in neonatal diabetes: an international cohort study
Background Traditional genetic testing focusses on analysis of one or a few genes
according to clinical features; this approach is changing as improved sequencing methods …
according to clinical features; this approach is changing as improved sequencing methods …
The missing link between genetic association and regulatory function
The genetic basis of most traits is highly polygenic and dominated by non-coding alleles. It is
widely assumed that such alleles exert small regulatory effects on the expression of cis …
widely assumed that such alleles exert small regulatory effects on the expression of cis …
GATA transcription factors in development and disease
M Tremblay, O Sanchez-Ferras, M Bouchard - Development, 2018 - journals.biologists.com
The GATA family of transcription factors is of crucial importance during embryonic
development, playing complex and widespread roles in cell fate decisions and tissue …
development, playing complex and widespread roles in cell fate decisions and tissue …
The emerging role of GATA transcription factors in development and disease
MHFM Lentjes, HEC Niessen, Y Akiyama… - Expert reviews in …, 2016 - cambridge.org
The GATA family of transcription factors consists of six proteins (GATA1-6) which are
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …
FOXA2 is required for enhancer priming during pancreatic differentiation
Transcriptional regulatory mechanisms of lineage priming in embryonic development are
largely uncharacterized because of the difficulty of isolating transient progenitor populations …
largely uncharacterized because of the difficulty of isolating transient progenitor populations …
Cellular and molecular mechanisms coordinating pancreas development
A Bastidas-Ponce, K Scheibner, H Lickert… - …, 2017 - journals.biologists.com
The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …
systemic glucose metabolism and food digestion through the function of its endocrine and …
Genome editing in hPSCs reveals GATA6 haploinsufficiency and a genetic interaction with GATA4 in human pancreatic development
Human disease phenotypes associated with haploinsufficient gene requirements are often
not recapitulated well in animal models. Here, we have investigated the association …
not recapitulated well in animal models. Here, we have investigated the association …