One is not enough: understanding and modeling polysubstance use

EA Crummy, TJ O'Neal, BM Baskin… - Frontiers in …, 2020 - frontiersin.org
Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …

Dopamine, behavior, and addiction

RA Wise, CJ Jordan - Journal of biomedical science, 2021 - Springer
Addictive drugs are habit-forming. Addiction is a learned behavior; repeated exposure to
addictive drugs can stamp in learning. Dopamine-depleted or dopamine-deleted animals …

Cannabinoids and the endocannabinoid system in reward processing and addiction: from mechanisms to interventions

R Spanagel - Dialogues in clinical neuroscience, 2020 - Taylor & Francis
The last decades have seen a major gain in understanding the action of cannabinoids and
the endocannabinoid system in reward processing and the development of addictive …

Cannabis effects on brain structure, function, and cognition: considerations for medical uses of cannabis and its derivatives

AC Burggren, A Shirazi, N Ginder… - The American journal of …, 2019 - Taylor & Francis
Background: Cannabis is the most widely used illicit substance worldwide, and legalization
for recreational and medical purposes has substantially increased its availability and use in …

Vaporized cannabis extracts have reinforcing properties and support conditioned drug-seeking behavior in rats

TG Freels, LN Baxter-Potter, JM Lugo… - Journal of …, 2020 - Soc Neuroscience
Recent trends in cannabis legalization have increased the necessity to better understand
the effects of cannabis use. Animal models involving traditional cannabinoid self …

Molecular mechanism and cannabinoid pharmacology

LD Schurman, D Lu, DA Kendall, AC Howlett… - … Use Disorders: From …, 2020 - Springer
Since antiquity, Cannabis has provoked enormous intrigue for its potential medicinal
properties as well as for its unique pharmacological effects. The elucidation of its major …

Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings

AJ Kesner, DM Lovinger - Journal of neurochemistry, 2021 - Wiley Online Library
Cannabis sativa is the most widely used illicit drug in the world. Its main psychoactive
component is delta‐9‐tetrahydrocannabinol (THC), one of over 100 phytocannabinoid …

Sex differences in the neuropsychiatric effects and pharmacokinetics of cannabidiol: A scoping review

J Matheson, Z Bourgault, B Le Foll - Biomolecules, 2022 - mdpi.com
Cannabidiol (CBD) is a non-intoxicating cannabinoid compound with diverse molecular
targets and potential therapeutic effects, including effects relevant to the treatment of …

Sex as a biological variable: Drug use and abuse

AL Riley, BJ Hempel, MM Clasen - Physiology & behavior, 2018 - Elsevier
The study of sex as a biological variable is a necessary emphasis across a wide array of
endpoints, including basic neuroscience, medicine, mental health, physiology and behavior …

Effects in rats of adolescent exposure to cannabis smoke or THC on emotional behavior and cognitive function in adulthood

AW Bruijnzeel, P Knight, S Panunzio, S Xue… - …, 2019 - Springer
Rationale Cannabis use is common among adolescents and some research suggests that
adolescent cannabis use increases the risk for depression, anxiety, and cognitive …