Background Current projections of the scale of the coming dementia epidemic assume that
the age-and sex-specific prevalence of dementia will not vary over time, and that population …

Cardiovascular (CV) disease is a leading cause of death worldwide, accounting for
approximately 31.4% of deaths globally in 2012. It is estimated that, from 1980 to 2000 …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Background Modifiable vascular and lifestyle-related risk factors have been associated with
dementia risk in observational studies. In the Finnish Geriatric Intervention Study to Prevent …

Motivation: The goal of fine-mapping in genomic regions associated with complex diseases
and traits is to identify causal variants that point to molecular mechanisms behind the …

Background—High-throughput profiling of circulating metabolites may improve
cardiovascular risk prediction over established risk factors. Methods and Results—We …

We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …

Objectives To study the effect of long term exposure to airborne pollutants on the incidence
of acute coronary events in 11 cohorts participating in the European Study of Cohorts for Air …

The population-based National FINRISK Study (later FINRISK Study) was initiated in 1972 in
Finland to carry out the evaluation of the North Karelia Project, a large community-based …

Aims Genetics plays an important role in coronary heart disease (CHD) but the clinical utility
of genomic risk scores (GRSs) relative to clinical risk scores, such as the Framingham Risk …