Organizational principles of 3D genome architecture
Studies of 3D chromatin organization have suggested that chromosomes are hierarchically
organized into large compartments composed of smaller domains called topologically …
organized into large compartments composed of smaller domains called topologically …
On the existence and functionality of topologically associating domains
JA Beagan, JE Phillips-Cremins - Nature genetics, 2020 - nature.com
Genomes across a wide range of eukaryotic organisms fold into higher-order chromatin
domains. Topologically associating domains (TADs) were originally discovered empirically …
domains. Topologically associating domains (TADs) were originally discovered empirically …
Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells
INTRODUCTION Chromatin adopts an intricate three-dimensional (3D) organization in the
nucleus that is critical for many genome processes, from gene regulation to genome …
nucleus that is critical for many genome processes, from gene regulation to genome …
[HTML][HTML] The energetics and physiological impact of cohesin extrusion
Cohesin extrusion is thought to play a central role in establishing the architecture of
mammalian genomes. However, extrusion has not been visualized in vivo, and thus, its …
mammalian genomes. However, extrusion has not been visualized in vivo, and thus, its …
Principles of genome folding into topologically associating domains
Understanding the mechanisms that underlie chromosome folding within cell nuclei is
essential to determine the relationship between genome structure and function. The recent …
essential to determine the relationship between genome structure and function. The recent …
[HTML][HTML] High-resolution TADs reveal DNA sequences underlying genome organization in flies
Despite an abundance of new studies about topologically associating domains (TADs), the
role of genetic information in TAD formation is still not fully understood. Here we use our …
role of genetic information in TAD formation is still not fully understood. Here we use our …
[HTML][HTML] Ever-changing landscapes: transcriptional enhancers in development and evolution
HK Long, SL Prescott, J Wysocka - Cell, 2016 - cell.com
A class of cis-regulatory elements, called enhancers, play a central role in orchestrating
spatiotemporally precise gene-expression programs during development. Consequently …
spatiotemporally precise gene-expression programs during development. Consequently …
[HTML][HTML] Systematic evaluation of chromosome conformation capture assays
Chromosome conformation capture (3C) assays are used to map chromatin interactions
genome-wide. Chromatin interaction maps provide insights into the spatial organization of …
genome-wide. Chromatin interaction maps provide insights into the spatial organization of …
Emerging roles of linker histones in regulating chromatin structure and function
DV Fyodorov, BR Zhou, AI Skoultchi… - Nature reviews Molecular …, 2018 - nature.com
Together with core histones, which make up the nucleosome, the linker histone (H1) is one
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …
[HTML][HTML] Chromatin domains: the unit of chromosome organization
How eukaryotic chromosomes fold inside the nucleus is an age-old question that remains
unanswered today. Early biochemical and microscopic studies revealed the existence of …
unanswered today. Early biochemical and microscopic studies revealed the existence of …