Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

Current cancer immunotherapies are primarily predicated on αβ T cells, with a stringent
dependence on MHC-mediated presentation of tumour-enriched peptides or unique …

Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

The metastatic spread of malignant cells to distant anatomical locations is a prominent
cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms …

T cells of the γδ lineage are unconventional T cells with functions not restricted to MHC-
mediated antigen presentation. Because of their broad antigen specificity and NK-like …

The potential of cancer immunotherapy relies on the mobilization of immune cells capable of
producing antitumour cytokines and effectively killing tumour cells. These are major …

Polymorphisms in the human leukocyte antigen (HLA) class I genes can cause the rejection
of pluripotent stem cell (PSC)-derived products in allogeneic recipients. Disruption of the …

With the promise of T cell-based therapy for cancer finally becoming reality, this Review
focuses on the less-studied γδ T cell lineage and its diverse responses to tumours. γδ T cells …

The immune system plays a major role in the surveillance against tumors. To avoid attack
from the immune system, tumor cells develop different strategies to escape immune …