Lung-on-a-chip: the future of respiratory disease models and pharmacological studies
J Shrestha, S Razavi Bazaz… - Critical reviews in …, 2020 - Taylor & Francis
Abstract Recently, organ-on-a-chip models, which are microfluidic devices that mimic the
cellular architecture and physiological environment of an organ, have been developed and …
cellular architecture and physiological environment of an organ, have been developed and …
Modeling host-pathogen interactions in the context of the microenvironment: three-dimensional cell culture comes of age
Tissues and organs provide the structural and biochemical landscapes upon which
microbial pathogens and commensals function to regulate health and disease. While flat two …
microbial pathogens and commensals function to regulate health and disease. While flat two …
In vitro models to study human lung development, disease and homeostasis
The main function of the lung is to support gas exchange, and defects in lung development
or diseases affecting the structure and function of the lung can have fatal consequences …
or diseases affecting the structure and function of the lung can have fatal consequences …
Regeneration of the lung: Lung stem cells and the development of lung mimicking devices
KAA Schilders, E Eenjes, S van Riet, AA Poot… - Respiratory …, 2016 - Springer
Inspired by the increasing burden of lung associated diseases in society and an growing
demand to accommodate patients, great efforts by the scientific community produce an …
demand to accommodate patients, great efforts by the scientific community produce an …
Lung organoids—the ultimate tool to dissect pulmonary diseases?
V Bosáková, M De Zuani, L Sládková… - Frontiers in Cell and …, 2022 - frontiersin.org
Organoids are complex multicellular three-dimensional (3D) in vitro models that are
designed to allow accurate studies of the molecular processes and pathologies of human …
designed to allow accurate studies of the molecular processes and pathologies of human …
Insulin-like growth factor 1 supports a pulmonary niche that promotes type 3 innate lymphoid cell development in newborn lungs
Type 3 innate lymphoid cells (ILC3s) are critical for lung defense against bacterial
pneumonia in the neonatal period, but the signals that guide pulmonary ILC3 development …
pneumonia in the neonatal period, but the signals that guide pulmonary ILC3 development …
Human-Based Advanced in vitro Approaches to Investigate Lung Fibrosis and Pulmonary Effects of COVID-19
M Kiener, N Roldan, C Machahua, A Sengupta… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic has caused considerable socio-
economic burden, which fueled the development of treatment strategies and vaccines at an …
economic burden, which fueled the development of treatment strategies and vaccines at an …
Matrix biomechanics and dynamics in pulmonary fibrosis
AJ Haak, Q Tan, DJ Tschumperlin - Matrix Biology, 2018 - Elsevier
The composition and mechanical properties of the extracellular matrix are dramatically
altered during the development and progression of pulmonary fibrosis. Recent evidence …
altered during the development and progression of pulmonary fibrosis. Recent evidence …
Organoids as a model system for studying human lung development and disease
RR Nadkarni, S Abed, JS Draper - Biochemical and biophysical research …, 2016 - Elsevier
The lung is a complex organ comprising multiple cell types that perform a variety of vital
processes, including immune defense and gas exchange. Diseases of the lung, such as …
processes, including immune defense and gas exchange. Diseases of the lung, such as …
Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer‐associated fibroblasts
Cancer‐associated fibroblasts (CAFs) are known to promote tumourigenesis through
various mechanisms. Fibroblast growth factor (FGF)/FGF receptor (FGFR)‐dependent lung …
various mechanisms. Fibroblast growth factor (FGF)/FGF receptor (FGFR)‐dependent lung …