[HTML][HTML] From animal poisons and venoms to medicines: achievements, challenges and perspectives in drug discovery

KCF Bordon, CT Cologna, EC Fornari-Baldo… - Frontiers in …, 2020 - frontiersin.org
Animal poisons and venoms are comprised of different classes of molecules displaying wide-
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …

[HTML][HTML] Scorpion venom: detriments and benefits

S Ahmadi, JM Knerr, L Argemi, KCF Bordon, MB Pucca… - Biomedicines, 2020 - mdpi.com
Scorpion venom may cause severe medical complications and untimely death if injected into
the human body. Neurotoxins are the main components of scorpion venom that are known to …

A global accounting of medically significant scorpions: Epidemiology, major toxins, and comparative resources in harmless counterparts

MJ Ward, SA Ellsworth, GS Nystrom - Toxicon, 2018 - Elsevier
Scorpions are an ancient and diverse venomous lineage, with over 2200 currently
recognized species. Only a small fraction of scorpion species are considered harmful to …

[HTML][HTML] Kv1. 3 channel as a key therapeutic target for neuroinflammatory diseases: state of the art and beyond

X Wang, G Li, J Guo, Z Zhang, S Zhang, Y Zhu… - Frontiers in …, 2020 - frontiersin.org
It remains a challenge for the effective treatment of neuroinflammatory disease, including
multiple sclerosis (MS), stroke, epilepsy, and Alzheimer's and Parkinson's disease. The …

[HTML][HTML] Voltage-gated potassium channels as regulators of cell death

M Bachmann, W Li, MJ Edwards, SA Ahmad… - Frontiers in cell and …, 2020 - frontiersin.org
Ion channels allow the flux of specific ions across biological membranes, thereby
determining ion homeostasis within the cells. Voltage-gated potassium-selective ion …

[HTML][HTML] Scorpion venom peptides: Molecular diversity, structural characteristics, and therapeutic use from channelopathies to viral infections and cancers

Z Xia, D He, Y Wu, HF Kwok, Z Cao - Pharmacological Research, 2023 - Elsevier
Animal venom is an important evolutionary innovation in nature. As one of the most
representative animal venoms, scorpion venom contains an extremely diverse set of …

[HTML][HTML] Why to study peptides from venomous and poisonous animals?

AN de Oliveira, AM Soares, SL Da Silva - International Journal of Peptide …, 2023 - Springer
Venom and poison peptides are powerful biological weapons and have proven immense
pharmacological potential because of their high binding affinity to a wide range of molecular …

Bioactive peptides from scorpion venoms: therapeutic scaffolds and pharmacological tools

KP Muiruri, J Zhong, YAO Bing, LAI Ren… - Chinese Journal of …, 2023 - Elsevier
Evolution and natural selection have endowed animal venoms, including scorpion venoms,
with a wide range of pharmacological properties. Consequently, scorpions, their venoms …

Scorpion envenomation and inflammation: Beyond neurotoxic effects

MB Reis, KF Zoccal, LG Gardinassi, LH Faccioli - Toxicon, 2019 - Elsevier
Scorpion envenomation results in a wide range of clinical manifestations that are mostly
attributed to the activation of the autonomic nervous system by venom toxins. In fact …

[HTML][HTML] Effects of Brazilian scorpion venoms on the central nervous system

ALA Nencioni, E Beraldo Neto, LA Freitas… - Journal of venomous …, 2018 - SciELO Brasil
In Brazil, the scorpion species responsible for most severe incidents belong to the Tityus
genus and, among this group, T. serrulatus, T. bahiensis, T. stigmurus and T. obscurus are …