Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, with a median survival
time of 10-12 months. Clinically, these poor outcomes are attributed to several factors …

Since the 2013 Nobel Prize was awarded for the discovery of vesicle trafficking, a subgroup
of nanovesicles called exosomes has been driving the research field to a new regime for …

Pancreatic ductal adenocarcinoma, as one of the most aggressive cancers, is characterized
by rich desmoplastic stroma that forms a physical barrier for anticancer drugs. To address …

MicroRNAs (miRNA) are small non-coding RNAs (∼ 22 nt in length) that are known as
potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a …

Simple Summary This review depicts the principal mechanisms involved in the process of
stromal desmoplasia characterizing pancreatic ductal adenocarcinoma (PDAC). The aim of …

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths in the
United States. The deoxynucleoside analogue gemcitabine is among the most effective …

Pancreatic stellate cells (PSCs) are the major contributor to the aggressive, metastatic, and
resilient nature of pancreatic ductal adenocarcinoma (PDAC), which has a poor prognosis …

Pancreatic ductal adenocarcinoma (PDAC) has one of the most dismal prognoses of all
cancers due to its late manifestation and resistance to current therapies. Accumulating …

Nitric oxide (NO) is an endogenous, multipotent biological signaling molecule that
participates in several physiological processes. Recently, exogenous supplementation of …