Behavioral mechanisms underlying nicotine reinforcement

LE Rupprecht, TT Smith, RL Schassburger… - … of nicotine dependence, 2015 - Springer
Cigarette smoking is the leading cause of preventable deaths worldwide, and nicotine, the
primary psychoactive constituent in tobacco, drives sustained use. The behavioral actions of …

[HTML][HTML] Focus: addiction: how menthol alters tobacco-smoking behavior: a biological perspective

RJ Wickham - The Yale journal of biology and medicine, 2015 - ncbi.nlm.nih.gov
Mentholated cigarettes gained popularity in the 1950s and were often marketed as “healthy”
cigarettes, attributable to their pleasurable mint flavor and cooling sensation in the mouth …

Mechanistic insights into the role of plant polyphenols and their nano-formulations in the management of depression

A Kabra, R Garg, J Brimson, J Živković… - Frontiers in …, 2022 - frontiersin.org
Depression is a condition characterized by low mood and an aversion to activity, that causes
behavioral problems, poor quality of life and limits daily life activities. It is considered as the …

Reduced nicotine product standards for combustible tobacco: building an empirical basis for effective regulation

EC Donny, DK Hatsukami, NL Benowitz, AF Sved… - Preventive …, 2014 - Elsevier
Abstract Introduction Both the Tobacco Control Act in the US and Article 9 of the Framework
Convention on Tobacco Control enable governments to directly address the addictiveness …

Nicotine reduction in cigarettes: literature review and gap analysis

ML Berman, AM Glasser - Nicotine and Tobacco Research, 2019 - academic.oup.com
Abstract Background The US Food and Drug Administration (FDA) is considering reducing
nicotine levels in cigarettes to “minimally or non-addictive levels.” However, important …

Sex differences in nicotine self-administration in rats during progressive unit dose reduction: implications for nicotine regulation policy

P Grebenstein, D Burroughs, Y Zhang… - Pharmacology …, 2013 - Elsevier
Reducing the nicotine content in tobacco products is being considered by the FDA as a
policy to reduce the addictiveness of tobacco products. Understanding individual differences …

Evaluating oral flavorant effects on nicotine self-administration behavior and phasic dopamine signaling

RJ Wickham, EJ Nunes, S Hughley, P Silva… - …, 2018 - Elsevier
Understanding how tobacco product flavor additives, such as flavorants in electronic
cigarettes, influence smoking behavior and addiction is critical for informing public health …

[图书][B] Advisory note: global nicotine reduction strategy: WHO Study Group on Tobacco Product Regulation

World Health Organization - 2015 - apps.who.int
The WHO Study Group on Tobacco Product Regulation (TobReg) 31is mandated to provide
the WHO Director-General with scientifically sound, evidence-based recommendations for …

Effects of monoamine oxidase inhibition on the reinforcing properties of low-dose nicotine

TT Smith, LE Rupprecht, SN Cwalina… - …, 2016 - nature.com
Abstract The Food and Drug Administration (FDA) has the authority to regulate cigarette
smoke constituents, and a reduction in nicotine content might benefit public health by …

Effects of MAO inhibition and a combination of minor alkaloids, β-carbolines, and acetaldehyde on nicotine self-administration in adult male rats

TT Smith, MB Schaff, LE Rupprecht… - Drug and alcohol …, 2015 - Elsevier
Introduction Although nicotine is the primary reinforcing constituent in cigarettes, there is
evidence that other constituents in cigarette smoke may interact with nicotine to reinforce …