Background: Naphthoquinones are a class of aromatic compounds relevant for their
chemical characteristics, structural properties, and biological activity. These compounds are …

Abstract A novel ethyl 3-amino-2-cyano-6-hydroxy-7, 12-dioxo-2, 7, 12, 12a-tetrahydro-1H-
benzo [g] pyrimido [1, 2-a] quinoline-5-carboxylate (3ABPQC) was synthesized by treating …

Equisetum myriochaetum is a semi-aquatic plant found on riverbanks that is commonly used
in traditional medicine as a diuretic agent. Additionally, the genus Equisetum stands out for …

American trypanosomiasis is a worldwide health problem that requires attention due to
ineffective treatment options. We evaluated n-butyl and isobutyl quinoxaline-7-carboxylate 1 …

A series of 11-substituted 3, 5, 10, 11-tetrahydro-2 H-benzo [6, 7] thiochromeno [2, 3-d][1, 3]
thiazole-2, 5, 10-triones were obtained via hetero-Diels-Alder reaction of 5 …

In this study, four novel naphthoquinone-thiazole hybrids bearing adamantane were
synthesized by reaction of naphthoquinone-aroylthiourea derivatives with 1-adamantyl …

Chagas disease is an endemic American parasitosis, caused by Trypanosoma cruzi. The
current therapies, benznidazole (BZN) and nifurtimox (NFX), show limited efficacy and …

Phenothiazine derivatives can unselectively inhibit the trypanothione‐dependent antioxidant
system enzyme trypanothione reductase (TR). A virtual screening of 2163 phenothiazine …

A series of sixteen benzoylthioureas derivatives were initially evaluated in vitro against the
epimastigote form of Trypanosoma cruzi. All of the tested compounds inhibited the growth of …

In continuation our effort to research the chemical space of aryloxy-naphthoquinones as
potential anti-Chagas agents, we synthesized nine derivatives and these compounds were …