Vascular calcification is associated with a significant increase in all-cause mortality and
atherosclerotic plaque rupture. Calcification has been determined to be an active process …

Our populations are aging. Some experts predict that 30% of hospital beds will soon be
occupied by osteoporosis patients. Statistics show that 20% of patients suffering from an …

Vascular calcification is a hallmark of atherosclerosis. The location, density, and confluence
of calcification may change portions of the arterial conduit to a noncompliant structure …

Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be
observed both at the cartilage surface and in its deeper layers. The formation of calcium …

Glycosylation is the most abundant and complex protein modification, and can have a
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …

Vascular calcification is highly prevalent and, when present, is associated with major
adverse cardiovascular events. Vascular smooth muscle cells play an integral role in …

Fetuin-A is a heterodimeric plasma glycoprotein containing an A-chain of 282 amino acids
and a B-chain of 27 amino acid residues linked by a single inter-disulfide bond. It is …

The involvement of collagen in bone biomineralization is commonly admitted, yet its role
remains unclear. Here we show that type I collagen in vitro can initiate and orientate the …

In this contribution, we review the recent literature on an alternative crystallization pathway
involving stable clusters prior to nucleation and show that the prenucleation cluster pathway …

Calcium oxalate (CaOx) kidney stones are formed attached to Randall's plaques (RPs) or
Randall's plugs. Mechanisms involved in the formation and growth are poorly understood. It …