The neurodevelopmental and dopamine hypotheses are leading theories of the
pathoetiology of schizophrenia, but they were developed in isolation. However, since they …

Over the last five decades, a large body of evidence has accrued for structural and metabolic
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …

The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

Animal and human postmortem studies provide evidence for changes in gamma-
aminobutyric acid (GABA) and glutamate in prefrontal cortex (PFC) during adolescence …

Schizophrenia is a leading cause of global disability. Current pharmacotherapy for the
disease predominantly uses one mechanism—dopamine D2 receptor blockade—but often …

Cell stress and impaired oxidative phosphorylation are central to mechanisms of synaptic
loss and neurodegeneration in the cellular pathology of Alzheimer's disease (AD). In this …

The brain is the central and most complex organ in the nervous system, comprising billions
of neurons that constantly communicate through trillions of connections called synapses …

In recent years, the field of neuroimaging dramatically moved forward by means of the
expeditious development of specific radioligands of novel targets. Among these targets, the …

PET technology has produced many radiopharmaceuticals that target specific brain proteins
and other measures of brain function. Recently, a new approach has emerged to image …

Abnormalities in neocortical and synaptic development are linked to neurodevelopmental
disorders. However, the molecular and cellular mechanisms governing initial synapse …