Ferroptosis: mechanisms and links with diseases

H Yan, T Zou, Q Tuo, S Xu, H Li, AA Belaidi… - Signal transduction and …, 2021 - nature.com
Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis,
autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by …

Ferroptosis: molecular mechanisms and health implications

D Tang, X Chen, R Kang, G Kroemer - Cell research, 2021 - nature.com
Cell death can be executed through different subroutines. Since the description of
ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been …

Ferroptosis: machinery and regulation

X Chen, J Li, R Kang, DJ Klionsky, D Tang - Autophagy, 2021 - Taylor & Francis
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …

Oxidative damage and antioxidant defense in ferroptosis

F Kuang, J Liu, D Tang, R Kang - Frontiers in cell and developmental …, 2020 - frontiersin.org
Many new types of regulated cell death have been recently implicated in human health and
disease. These regulated cell deaths have different morphological, genetic, biochemical …

[HTML][HTML] The emerging role of ferroptosis in inflammation

Y Sun, P Chen, B Zhai, M Zhang, Y Xiang… - Biomedicine & …, 2020 - Elsevier
Ferroptosis is a newly discovered type of cell death triggered by intracellular phospholipid
peroxidation that is morphologically, biologically and genetically distinct from other types of …

Nrf2 and ferroptosis: a new research direction for neurodegenerative diseases

X Song, D Long - Frontiers in neuroscience, 2020 - frontiersin.org
Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of
intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which …

[HTML][HTML] Is melatonin the cornucopia of the 21st century?

N Ferlazzo, G Andolina, A Cannata, MG Costanzo… - Antioxidants, 2020 - mdpi.com
Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and
extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) …

Can melatonin reduce the severity of COVID-19 pandemic?

A Shneider, A Kudriavtsev… - International reviews of …, 2020 - Taylor & Francis
The current COVID-19 pandemic is one of the most devastating events in recent history. The
virus causes relatively minor damage to young, healthy populations, imposing life …

Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis

T Rui, H Wang, Q Li, Y Cheng, Y Gao… - Journal of Pineal …, 2021 - Wiley Online Library
Accumulating evidence demonstrates that ferroptosis may be important in the
pathophysiological process of traumatic brain injury (TBI). As a major hormone of the pineal …

Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury

C Wang, W Yuan, A Hu, J Lin… - Molecular …, 2020 - spandidos-publications.com
Cardiac dysfunction resulting from sepsis may cause significant morbidity and mortality, and
ferroptosis plays a role in this pathology. Dexmedetomidine (Dex), a α2‑adrenergic receptor …