Little fish, big data: zebrafish as a model for cardiovascular and metabolic disease
The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …
emergence of systems approaches in biology promises new therapies, faster and cheaper …
Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing
Prolonged unaccustomed exercise involving muscle lengthening (eccentric) actions can
result in ultrastructural muscle disruption, impaired excitation–contraction coupling …
result in ultrastructural muscle disruption, impaired excitation–contraction coupling …
The role of Z-disc proteins in myopathy and cardiomyopathy
K Wadmore, AJ Azad, K Gehmlich - International Journal of Molecular …, 2021 - mdpi.com
The Z-disc acts as a protein-rich structure to tether thin filament in the contractile units, the
sarcomeres, of striated muscle cells. Proteins found in the Z-disc are integral for maintaining …
sarcomeres, of striated muscle cells. Proteins found in the Z-disc are integral for maintaining …
Cardiac transcriptome and dilated cardiomyopathy genes in zebrafish
Background—Genetic studies of cardiomyopathy and heart failure have limited throughput
in mammalian models. Adult zebrafish have been recently pursued as a vertebrate model …
in mammalian models. Adult zebrafish have been recently pursued as a vertebrate model …
Exome sequencing identifies a mutation in the ACTN2 gene in a family with idiopathic ventricular fibrillation, left ventricular noncompaction, and sudden death
RD Bagnall, LK Molloy, JM Kalman, C Semsarian - BMC medical genetics, 2014 - Springer
Background Potentially lethal and heritable cardiomyopathies and cardiac channelopathies
are caused by heterogeneous autosomal dominant mutations in over 50 distinct genes, and …
are caused by heterogeneous autosomal dominant mutations in over 50 distinct genes, and …
Alternative splicing mediated by RNA-binding protein RBM24 facilitates cardiac myofibrillogenesis in a differentiation stage-specific manner
SHA Lu, KZ Lee, PWC Hsu, LY Su, YC Yeh… - Circulation …, 2022 - Am Heart Assoc
Background: Mutations in genes encoding sarcomeric proteins lead to failures in sarcomere
assembly, the building blocks of contracting muscles, resulting in cardiomyopathies that are …
assembly, the building blocks of contracting muscles, resulting in cardiomyopathies that are …
Disruption of Z-disc function promotes mechanical dysfunction in human myocardium: evidence for a dual myofilament modulatory role by alpha-actinin 2
M Rodriguez Garcia, J Schmeckpeper… - International Journal of …, 2023 - mdpi.com
The ACTN2 gene encodes α-actinin 2, located in the Z-disc of the sarcomeres in striated
muscle. In this study, we sought to investigate the effects of an ACTN2 missense variant of …
muscle. In this study, we sought to investigate the effects of an ACTN2 missense variant of …
Trapping cardiac recessive mutants via expression-based insertional mutagenesis screening
Rationale: Mutagenesis screening is a powerful genetic tool for probing biological
mechanisms underlying vertebrate development and human diseases. However, the …
mechanisms underlying vertebrate development and human diseases. However, the …
New and TALENted genome engineering toolbox
JM Campbell, KA Hartjes, TJ Nelson, X Xu… - Circulation …, 2013 - Am Heart Assoc
Recent advances in the burgeoning field of genome engineering are accelerating the
realization of personalized therapeutics for cardiovascular disease. In the postgenomic era …
realization of personalized therapeutics for cardiovascular disease. In the postgenomic era …
Zebrafish as a model of cardiac disease
RN Wilkinson, C Jopling, FJM van Eeden - Progress in molecular biology …, 2014 - Elsevier
The zebrafish has been rapidly adopted as a model for cardiac development and disease.
The transparency of the embryo, its limited requirement for active oxygen delivery, and ease …
The transparency of the embryo, its limited requirement for active oxygen delivery, and ease …