Alzheimer's disease is a devastating neurodegenerative disorder with no cure. Countless
promising therapeutics have shown efficacy in rodent Alzheimer's disease models yet failed …

Neurodegenerative diseases have two general characteristics that are so fundamental we
usually take them for granted. The first is that the pathology associated with the disease only …

The drivers of sporadic Alzheimer's disease (AD) remain incompletely understood. Utilizing
directly converted induced neurons (iNs) from AD-patient-derived fibroblasts, we identified a …

The concept of senescence as a phenomenon limited to proliferating cells has been
challenged by growing evidence of senescence-like features in terminally differentiated …

Huntington's disease (HD) is an inherited neurodegenerative disorder with adult-onset
clinical symptoms, but the mechanism by which aging drives the onset of neurodegeneration …

It has been 15 years since the birth of human induced pluripotent stem cell (iPSC)
technology in 2007, and the scope of its application has been expanding. In addition to the …

Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …

Neurodegenerative diseases are the most common causes of disability worldwide. Given
their high prevalence, devastating symptoms, and lack of definitive diagnostic tests, there is …

Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary human and financial burdens. Studies of …

Age-associated neurological diseases represent a profound challenge in biomedical
research as we are still struggling to understand the interface between the aging process …