The molecular mechanisms underlying atrial fibrillation (AF), the most common form of
arrhythmia, are poorly understood and therefore target-specific treatment options remain an …

Calcium signaling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is
bound to buffers, with typically only∼ 1% being freely ionized at resting levels in most cells …

Crucial conventional patch-clamp approaches to investigate cellular electrophysiology suffer
from low-throughput and require considerable experimenter expertise. Automated patch …

Sepsis is a known risk factor for new-onset atrial fibrillation (AF), and previous studies have
demonstrated that ferroptosis participates in sepsis-induced organ injury development …

Pre-existing Ca2+ handling abnormalities constitute the arrhythmogenic substrate in
patients developing postoperative atrial fibrillation (POAF), a common complication after …

Aims Atrial fibrillation (AF) is associated with tachycardia-induced cellular electrophysiology
alterations which promote AF chronification and treatment resistance. Development of novel …

Post-operative atrial fibrillation (POAF) is a persistent and serious surgical complication that
occur in 20-55% of cardiac surgery cases. POAF may lead to adverse health outcomes such …

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are increasingly
used for personalised medicine and preclinical cardiotoxicity testing. Reports on hiPSC-CM …

Mechano‐electric regulations (MER) play an important role in the maintenance of cardiac
performance. Mechano‐calcium and mechano‐electric feedback (MCF and MEF) pathways …

Post-operative Atrial fibrillation (POAF) is a common complication post cardiac surgery. It
can result in detrimental short-and long-term outcomes due to the increased risk of stroke …