PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer's disease and Parkinson's disease
HZ Long, Y Cheng, ZW Zhou, HY Luo… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) and Parkinson's disease (PD) are two typical neurodegenerative
diseases that increased with aging. With the emergence of aging population, the health …
diseases that increased with aging. With the emergence of aging population, the health …
Biological properties and clinical applications of berberine
D Song, J Hao, D Fan - Frontiers of Medicine, 2020 - Springer
Berberine, an isoquinoline alkaloid isolated from the Chinese herb Coptis chinensis and
other Berberis plants, has a wide range of pharmacological properties. Berberine can be …
other Berberis plants, has a wide range of pharmacological properties. Berberine can be …
The hormetic dose-response mechanism: Nrf2 activation
EJ Calabrese, WJ Kozumbo - Pharmacological Research, 2021 - Elsevier
A generalized mechanism for hormetic dose responses is proposed that is based on the
redox-activated transcription factor (TF), Nrf2, and its upregulation of an integrative system of …
redox-activated transcription factor (TF), Nrf2, and its upregulation of an integrative system of …
Shaping the Nrf2-ARE-related pathways in Alzheimer's and Parkinson's diseases
L Fão, SI Mota, AC Rego - Ageing Research Reviews, 2019 - Elsevier
A failure in redox homeostasis is a common hallmark of Alzheimer's Disease (AD) and
Parkinson's Disease (PD), two age-dependent neurodegenerative disorders (NDD), causing …
Parkinson's Disease (PD), two age-dependent neurodegenerative disorders (NDD), causing …
Activation of p62-Keap1-Nrf2 pathway protects 6-hydroxydopamine-induced ferroptosis in dopaminergic cells
Y Sun, L He, T Wang, W Hua, H Qin, J Wang… - Molecular …, 2020 - Springer
Parkinson's disease (PD) is a common neurodegenerative disorder primarily caused by the
death of dopaminergic neurons in the substantia nigra pars compacta (SNpc). However, the …
death of dopaminergic neurons in the substantia nigra pars compacta (SNpc). However, the …
Neurotoxin-induced animal models of Parkinson disease: pathogenic mechanism and assessment
XS Zeng, WS Geng, JJ Jia - ASN neuro, 2018 - journals.sagepub.com
Parkinson disease (PD) is the second most common neurodegenerative movement
disorder. Pharmacological animal models are invaluable tools to study the pathological …
disorder. Pharmacological animal models are invaluable tools to study the pathological …
Pharmacological modulation of Nrf2/HO-1 signaling pathway as a therapeutic target of Parkinson's disease
Y Wang, L Gao, J Chen, Q Li, L Huo, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD) is a complex neurodegenerative disorder featuring both motor and
nonmotor symptoms associated with a progressive loss of dopaminergic neurons in the …
nonmotor symptoms associated with a progressive loss of dopaminergic neurons in the …
Hormesis: path and progression to significance
EJ Calabrese - International journal of molecular sciences, 2018 - mdpi.com
This paper tells the story of how hormesis became recognized as a fundamental concept in
biology, affecting toxicology, microbiology, medicine, public health, agriculture, and all areas …
biology, affecting toxicology, microbiology, medicine, public health, agriculture, and all areas …
Zebrafish as a model organism for neurodegenerative disease
K Chia, A Klingseisen, D Sieger… - Frontiers in molecular …, 2022 - frontiersin.org
The zebrafish is increasingly recognized as a model organism for translational research into
human neuropathology. The zebrafish brain exhibits fundamental resemblance with human …
human neuropathology. The zebrafish brain exhibits fundamental resemblance with human …
Neuroprotective properties of berberine: Molecular mechanisms and clinical implications
Berberine (BBR), an isoquinoline alkaloid natural product, is isolated primarily from Coptis
chinensis and other Berberis plants. BBR possesses various bioactivities, including …
chinensis and other Berberis plants. BBR possesses various bioactivities, including …