Aberrant gene expression that drives human cancer can arise from epigenetic
dysregulation. Although much attention has focused on altered activity of transcription …

Abstract RNA-binding protein, musashi1 (MSI1), is a main protein in asymmetric cell division
of the sensory organ precursor cells, whereas its expression is reported to be upregulated in …

A recent outbreak of Zika virus in Brazil has led to a simultaneous increase in reports of
neonatal microcephaly. Zika targets cerebral neural precursors, a cell population essential …

Members of the Msi family of RNA-binding proteins have recently emerged as potent
oncoproteins in a range of malignancies. MSI2 is highly expressed in hematopoietic …

ABSTRACT RNA binding proteins have emerged as critical oncogenic factors and potential
targets in cancer therapy. In this study, we evaluated Musashi1 (Msi1) targeting as a strategy …

Regeneration of the intestinal epithelium is driven by multiple intestinal stem cell (ISC) types,
including an active, radiosensitive Wnthigh ISC that fuels turnover during homeostasis and a …

The mammalian MSI family of RNA-binding proteins (RBPs) have important roles as
oncoproteins in an array of tumor types, including leukemias, glioblastomas, and pancreatic …

Simple Summary Musashi–1 (MSI1) is an RNA–binding protein that promotes stemness
properties. It was initially discovered as a regulator of neuronal development and oocyte …

Intestinal stem cells (ISC s) fuel the lifelong self‐renewal of the intestinal tract and are
paramount for epithelial repair. In this context, the Wnt pathway component LGR 5 is the …

Congenital microcephaly causes smaller than average head circumference relative to age,
sex and ethnicity and is most usually associated with a variety of neurodevelopmental …