The impact of pre-existing cross-reactive immunity on SARS-CoV-2 infection and vaccine responses
Pre-existing cross-reactive immune responses to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) proteins in infection-naive subjects have been described by …
coronavirus 2 (SARS-CoV-2) proteins in infection-naive subjects have been described by …
Progress and pitfalls in the quest for effective SARS-CoV-2 (COVID-19) vaccines
There are currently around 200 SARS-CoV-2 candidate vaccines in preclinical and clinical
trials throughout the world. The various candidates employ a range of vaccine strategies …
trials throughout the world. The various candidates employ a range of vaccine strategies …
[HTML][HTML] Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination
During the SARS-CoV-2 pandemic, novel and traditional vaccine strategies have been
deployed globally. We investigated whether antibodies stimulated by mRNA vaccination …
deployed globally. We investigated whether antibodies stimulated by mRNA vaccination …
[HTML][HTML] Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses
Vaccines generate high-affinity antibodies by recruiting antigen-specific B cells to germinal
centers (GCs), but the mechanisms governing the recruitment to GCs on secondary …
centers (GCs), but the mechanisms governing the recruitment to GCs on secondary …
Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants
CJ Reynolds, JM Gibbons, C Pade, KM Lin… - Science, 2022 - science.org
The impact of the initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infecting strain on downstream immunity to heterologous variants of concern (VOCs) is …
infecting strain on downstream immunity to heterologous variants of concern (VOCs) is …
An influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults
AT Widge, AR Hofstetter, KV Houser, SF Awan… - Science translational …, 2023 - science.org
Influenza vaccines could be improved by platforms inducing cross-reactive immunity.
Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines …
Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines …
Development of a pentavalent broadly protective nucleoside-modified mRNA vaccine against influenza B viruses
Messenger RNA (mRNA) vaccines represent a new, effective vaccine platform with high
capacity for rapid development. Generation of a universal influenza virus vaccine with the …
capacity for rapid development. Generation of a universal influenza virus vaccine with the …
Vaccine-associated enhanced disease and pathogenic human coronaviruses
Vaccine-associated enhanced disease (VAED) is a difficult phenomenon to define and can
be confused with vaccine failure. Using studies on respiratory syncytial virus (RSV) …
be confused with vaccine failure. Using studies on respiratory syncytial virus (RSV) …
Stereotypic neutralizing VH antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individuals
Stereotypic antibody clonotypes exist in healthy individuals and may provide protective
immunity against viral infections by neutralization. We observed that 13 of 17 patients with …
immunity against viral infections by neutralization. We observed that 13 of 17 patients with …
Enhanced SARS-CoV-2 humoral immunity following breakthrough infection builds upon the preexisting memory B cell pool
T Weber, S Dähling, S Rose, P Affeldt… - Science …, 2023 - science.org
The human immune response must continuously adapt to newly emerging SARS-CoV-2
variants. To investigate how B cells respond to repeated SARS-CoV-2 antigen exposure by …
variants. To investigate how B cells respond to repeated SARS-CoV-2 antigen exposure by …