Advance in dietary polyphenols as dipeptidyl peptidase-IV inhibitors to alleviate type 2 diabetes mellitus: Aspects from structure-activity relationship and …
Y Jia, S Cai, B Muhoza, B Qi, Y Li - Critical Reviews in Food …, 2023 - Taylor & Francis
Dietary polyphenols with great antidiabetic effects are the most abundant components in
edible products. Dietary polyphenols have attracted attention as dipeptidyl peptidase-IV …
edible products. Dietary polyphenols have attracted attention as dipeptidyl peptidase-IV …
Pharmacological and Clinical Studies of Medicinal Plants That Inhibit Dipeptidyl Peptidase-IV
Abstract Dipeptidyl peptidase IV (DPP-IV) is an enzyme responsible for the degradation of
the incretin hormone glucagon-like peptide-1 (GLP-1). DPP-IV plays a significant role in …
the incretin hormone glucagon-like peptide-1 (GLP-1). DPP-IV plays a significant role in …
Novel potent and selective DPP-4 inhibitors: Design, synthesis and molecular docking study of dihydropyrimidine phthalimide hybrids
Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors have emerged as anti-hyperglycemic
agents that improve glycemic control in type 2 diabetic patients, either as monotherapy or in …
agents that improve glycemic control in type 2 diabetic patients, either as monotherapy or in …
Inhibitory activity of xanthoangelol isolated from Ashitaba (Angelica keiskei Koidzumi) towards α-glucosidase and dipeptidyl peptidase-IV: in silico and in vitro studies
In Indonesia, the sap of Angelica keiskei Koidzumi has been utilized traditionally as a blood-
sugar reducer, nonetheless, its molecular mechanism still needs to be studied. This study …
sugar reducer, nonetheless, its molecular mechanism still needs to be studied. This study …
Molecular docking and molecular dynamics studies of bioactive compounds contained in noni fruit (Morinda citrifolia L.) against human pancreatic α-amylase
Human pancreatic α-amylase inhibition is currently a promising therapeutic target against
type 2 diabetes (DMT2) because it can reduce aggressive digestion of carbohydrates into …
type 2 diabetes (DMT2) because it can reduce aggressive digestion of carbohydrates into …
4-Hydroxyderricin promotes apoptosis and cell cycle arrest through regulating PI3K/AKT/mTOR pathway in hepatocellular cells
X Gao, Y Jiang, Q Xu, F Liu, X Pang, M Wang, Q Li, Z Li - Foods, 2021 - mdpi.com
4-hydroxyderricin (4-HD), as a natural flavonoid compound derived from Angelica keiskei,
has largely unknown inhibition and mechanisms on liver cancer. Herein, we investigated the …
has largely unknown inhibition and mechanisms on liver cancer. Herein, we investigated the …
The Cytotoxicity and Nephroprotective Activity of the Ethanol Extracts of Angelica keiskei Koidzumi Stems and Leaves against the NAPQI‐Induced Human Embryonic …
Ethnopharmacological Relevance. In Indonesia, Angelica keiskei Koidzumi (ashitaba or
Japanese celery) has been traditionally used to maintain health and to achieve longevity …
Japanese celery) has been traditionally used to maintain health and to achieve longevity …
Nephroprotective Activity of Angelica keiskei (Miq). Koidz. on Cisplatin-Induced Rats: Reducing Serum Creatinine, Urea Nitrogen, KIM-1, and Suppressing NF …
I Wahyuni, DL Aulifa, AM Rosdianto… - Drug Design …, 2024 - Taylor & Francis
Background The sap of Angelica keiskei (Miq). Koidz. has been reported for its abundance
of chalcone contents. Chalcones have been known for their effective nephroprotective …
of chalcone contents. Chalcones have been known for their effective nephroprotective …
Identifying Potential Human Monoacylglycerol Lipase Inhibitors from the Phytoconstituents of Morinda Citrifolia L. Fruits by in silico Pharmacology and in vitro Study
Background Human monoacylglycerol lipase (MGL) is accountable for the hydrolysis of 2-
arachidonoylglycerol (2-AG), thus contributing pivotally to neuroprotection because 2-AG is …
arachidonoylglycerol (2-AG), thus contributing pivotally to neuroprotection because 2-AG is …
[PDF][PDF] Molecular docking of β-Sitosterol and stigmasterol isolated from Morinda citrifolia with α-amylase, α-glucosidase, dipeptidylpeptidase-IV, and peroxisome …
ABSTRACT In Indonesia, Morinda citrifolia (Rubiaceae) fruit has been traditionally used to
treat various diseases. A previous study confirmed the presence of flavonoids, terpenoids …
treat various diseases. A previous study confirmed the presence of flavonoids, terpenoids …