Designing an effective therapeutic siRNA to silence RdRp gene of SARS-CoV-2

MMAK Shawan, AR Sharma, M Bhattacharya… - Infection, Genetics and …, 2021 - Elsevier
The devastating outbreak of COVID-19 has spread all over the world and has become a
global health concern. There is no specific therapeutics to encounter the COVID-19. Small …

Design of siRNA molecules for silencing of membrane glycoprotein, nucleocapsid phosphoprotein, and surface glycoprotein genes of SARS-CoV2

VS Ayyagari - Journal of Genetic Engineering and Biotechnology, 2022 - Elsevier
The global COVID-19 pandemic caused by SARS-CoV2 infected millions of people and
resulted in more than 4 million deaths worldwide. Apart from vaccines and drugs, RNA …

Keratinocyte-derived IL-36γ plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes

JJ Pyo, S Ahn, SH Jin, S An, E Lee, J Choi, JC Shin… - Archives of …, 2019 - Springer
Chemical leukoderma is an acquired type of vitiligo that can be initiated by various
exogenous chemicals such as hydroquinone (HQ), rhododendrol (RD), or 4-tertiary butyl …

Exploring the potential of structural modeling and molecular docking for efficient siRNA screening: A promising approach to Combat viral mutants, with a focus on HIV …

M Nematian, Z Noormohammadi, P Rahimi… - Biochemical and …, 2024 - Elsevier
RNA interference (RNAi) holds immense potential for sequence-specific downregulation of
disease-related genes. Small interfering RNA (siRNA) therapy has made remarkable strides …

Genome-scale transcriptional profile analysis of human keratinocytes in response to hydroquinone

표정주 - 2020 - s-space.snu.ac.kr
Hydroquinone (HQ) is a well-known phenolic agent that can cause chemical leukoderma, a
pigmentary disorder characterized by the loss of functional melanotic melanocytes in human …