While Nature harnesses RNA and DNA to store, read and write genetic information, the
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …

The i-motif represents a paradigmatic example of the wide structural versatility of nucleic
acids. In remarkable contrast to duplex DNA, i-motifs are four-stranded DNA structures held …

Conspectus This Account highlights the structural features that render 2′-deoxy-2′-fluoro-
arabinonucleic acid (FANA) an ideal tool for mimicking DNA secondary structures and …

DNA sequences rich in cytosine have the propensity, under acidic pH, to fold into four‐
stranded intercalated DNA structures called i‐motifs. Recent studies have provided …

I-motifs (iMs) are four-stranded non-B DNA structures containing C-rich DNA sequences.
The formation of iMs is sensitive to pH conditions and DNA methylation, although the extent …

Abstract i-Motifs are widely used in nanotechnology, play a part in gene regulation and have
been detected in human nuclei. As these structures are composed of cytosine, they are …

G-quadruplex and i-motif nucleic acid structures are believed to fold through kinetic
partitioning mechanisms. Such mechanisms explain the structural heterogeneity of G …

Stabilizing i-motif structures at neutral pH and physiological temperature remains a major
challenge. Here, we demonstrate the use of chemical end-ligation to stabilize intramolecular …

An i-motif (iM) is a four-stranded (quadruplex) DNA structure that folds from cytosine (C)-rich
sequences. iMs can fold under many different conditions in vitro, which paves the way for …

Repetitive nucleic acid sequences, which occur in abundance throughout the mammalian
genome, are of enormous research interest due to their potential to adopt fascinating and …