Understanding the physiological role of NaV1. 9: Challenges and opportunities for pain modulation
W Brackx, R de Cássia Collaço, M Theys… - Pharmacology & …, 2023 - Elsevier
Abstract Voltage-activated Na+(Na V) channels are crucial contributors to rapid electrical
signaling in the human body. As such, they are among the most targeted membrane proteins …
signaling in the human body. As such, they are among the most targeted membrane proteins …
Pathology of pain and its implications for therapeutic interventions
B Cao, Q Xu, Y Shi, R Zhao, H Li, J Zheng… - … and Targeted Therapy, 2024 - nature.com
Pain is estimated to affect more than 20% of the global population, imposing incalculable
health and economic burdens. Effective pain management is crucial for individuals suffering …
health and economic burdens. Effective pain management is crucial for individuals suffering …
SHED-derived exosomes attenuate trigeminal neuralgia after CCI of the infraorbital nerve in mice via the miR-24-3p/IL-1R1/p-p38 MAPK pathway
R Guo, Y Fang, Y Zhang, L Liu, N Li, J Wu… - Journal of …, 2023 - Springer
Background Microglial activation in the spinal trigeminal nucleus (STN) plays a crucial role
in the development of trigeminal neuralgia (TN). The involvement of adenosine …
in the development of trigeminal neuralgia (TN). The involvement of adenosine …
Exploring the bidirectional causal associations between pain and circulating inflammatory proteins: A Mendelian randomization study
Y Wang, W Zhou, F Zhang, J Wei… - Clinical and …, 2024 - Wiley Online Library
Multisite chronic pain (MCP) and site‐specific chronic pain (SSCP) may be influenced by
circulating inflammatory proteins, but the causal relationship remains unknown. To …
circulating inflammatory proteins, but the causal relationship remains unknown. To …
Electroacupuncture prevents the development or establishment of chronic pain via IL-33/ST2 signaling in hyperalgesic priming model rats
Y Jin, J Zhou, Y Fang, H Song, S Lin, B Pan, L Liu… - Neuroscience …, 2024 - Elsevier
Background Chronic pain is a complex health issue. Compared to acute pain, which has a
protective value, chronic pain is defined as persistent pain after tissue injury. Few clinical …
protective value, chronic pain is defined as persistent pain after tissue injury. Few clinical …
[HTML][HTML] Neonatal Injury Modulates Incisional Pain Sensitivity in Adulthood: An Animal Study
K Soma, S Hitomi, Y Hayashi, C Soma, J Otsuji… - Neuroscience, 2023 - Elsevier
Neonatal pain experiences including traumatic injury influences negatively on development
of nociceptive circuit developments, resulting in persistent pain hypersensitivity in adults …
of nociceptive circuit developments, resulting in persistent pain hypersensitivity in adults …
A novel co-target of ACY1 governing plasma membrane translocation of SphK1 contributes to inflammatory and neuropathic pain
B Liu, W Wu, LL Cui, X Zheng, N Li, X Zhang, G Duan - Iscience, 2023 - cell.com
Previous studies validate that inhibiting sodium channel 1.8 (Nav1. 8) effectively relieves
inflammatory and neuropathic pain. However, Nav1. 8 blockers have cardiac side effects in …
inflammatory and neuropathic pain. However, Nav1. 8 blockers have cardiac side effects in …
[PDF][PDF] Participación del factor de necrosis tumoral α y el receptor TNFR1 en la alodinia táctil inducida por privación de sueño MOR en ratas
J González González - 2023 - repositorio.cinvestav.mx
El sueño es un estado fisiológico donde se presenta perdida de la conciencia, relajación
muscular y menor capacidad de reaccionar a estímulos externos (Fuller et al., 2006). El …
muscular y menor capacidad de reaccionar a estímulos externos (Fuller et al., 2006). El …